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Upper Respiratory Microbiota in Relation to Ear and Nose Health Among Australian Aboriginal and Torres Strait Islander Children
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- Coleman, Andrea (författare)
- Children's Health Research Centre, University of Queensland Centre for Clinical Research, South Brisbane, Australia; Department of Surgery-Otolaryngology, Head and Neck Surgery, Townsville University Hospital, Townsville, Australia
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- Bialasiewicz, Seweryn (författare)
- Australian Centre for Ecogenomics, University of Queensland, St Lucia, Australia; Queensland Pediatric Infectious Diseases Laboratory, Queensland Children's Hospital, South Brisbane, Australia
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- Marsh, Robyn L. (författare)
- Menzies School of Health Research, Charles Darwin University, Darwin, Australia
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- Håkansson, Eva Grahn (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Essum AB, Umeå, Sweden
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- Cottrell, Kyra (författare)
- University of Queensland Centre for Clinical Research, Herston, Australia
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- Wood, Amanda (författare)
- Queensland Health Deadly Ears Program, Brisbane, Australia
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- Jayasundara, Nadeesha (författare)
- Queensland Pediatric Infectious Diseases Laboratory, Queensland Children's Hospital, South Brisbane, Australia
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- Ware, Robert S. (författare)
- Menzies Health Institute Queensland, Griffith University, Brisbane, Australia
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- Zaugg, Julian (författare)
- Children's Health Research Centre, University of Queensland Centre for Clinical Research, South Brisbane, Australia
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- Sidjabat, Hanna E. (författare)
- University of Queensland Centre for Clinical Research, Herston, Australia
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- Adams, Jasmyn (författare)
- Queensland Health Deadly Ears Program, Brisbane, Australia
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- Ferguson, Josephine (författare)
- Queensland Health Deadly Ears Program, Brisbane, Australia
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- Brown, Matthew (författare)
- Queensland Health Deadly Ears Program, Brisbane, Australia
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- Roos, Kristian (författare)
- ENT Department, Lundby Hospital, Gothenburg, Sweden
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- Cervin, Anders (författare)
- University of Queensland Centre for Clinical Research, Herston, Australia; Department of Otolaryngology, Head and Neck Surgery, The Royal Brisbane and Women's Hospital, Brisbane, Australia
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(creator_code:org_t)
- 2021-01-04
- 2021
- Engelska.
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Ingår i: Journal of the Pediatric Infectious Diseases Society. - : Oxford University Press. - 2048-7207. ; 10:4, s. 468-476
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: We explored the nasal microbiota in Indigenous Australian children in relation to ear and nasal health.METHODS: In total, 103 Indigenous Australian children aged 2-7 years (mean 4.7 years) were recruited from 2 Queensland communities. Children's ears, nose, and throats were examined and upper respiratory tract (URT) swabs collected. Clinical histories were obtained from parents/medical records. URT microbiota were characterized using culturomics with Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) identification. Real-time PCR was used to quantify otopathogen (Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) loads and detect respiratory viruses. Data were analyzed using beta diversity measures, regression modeling, and a correlation network analysis.RESULTS: Children with historical/current otitis media (OM) or URT infection (URTI) had higher nasal otopathogen detection and loads and rhinovirus detection compared with healthy children (all P < .04). Children with purulent rhinorrhea had higher nasal otopathogen detection and loads and rhinovirus detection (P < .04) compared with healthy children. High otopathogen loads were correlated in children with historical/current OM or URTI, whereas Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum were correlated in healthy children.CONCLUSIONS: Corynebacterium pseudodiphtheriticum and D. pigrum are associated with URT and ear health. The importance of the main otopathogens in URT disease/OM was confirmed, and their role relates to co-colonization and high otopathogens loads.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Nyckelord
- Indigenous Australian
- microbiota
- nose
- otitis media
- otopathogen
- respiratory virus
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- Av författaren/redakt...
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Coleman, Andrea
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Bialasiewicz, Se ...
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Marsh, Robyn L.
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Håkansson, Eva G ...
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Cottrell, Kyra
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Wood, Amanda
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Jayasundara, Nad ...
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Ware, Robert S.
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Zaugg, Julian
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Sidjabat, Hanna ...
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Adams, Jasmyn
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Ferguson, Joseph ...
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Brown, Matthew
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Roos, Kristian
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Cervin, Anders
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