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Biological Effect o...
Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer
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- Lagopati, Nefeli (author)
- Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece
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- Kotsinas, Athanassios (author)
- Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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- Veroutis, Dimitris (author)
- Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece
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- Evangelou, Konstantinos (author)
- Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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- Papaspyropoulos, Angelos (author)
- Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece
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- Arfanis, Michalis (author)
- Institute of Nanoscience and Nanotechnology, Laboratory of Nanotechnology Processes for Solar Energy Conversion and Environmental Protection, National Centre for Scientific Research "Demokritos", Athens, Greece
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- Falaras, Polycarpos (author)
- Institute of Nanoscience and Nanotechnology, Laboratory of Nanotechnology Processes for Solar Energy Conversion and Environmental Protection, National Centre for Scientific Research "Demokritos", Athens, Greece
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- Kitsiou, Paraskevi V. (author)
- Institute of Biosciences and Applications, Laboratory of Biochemistry/Cell & Matrix Pathobiology, National Centre for Scientific Research "Demokritos", Athens, Greece
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- Pateras, Ioannis (author)
- Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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- Bergonzini, Anna (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Frisan, Teresa, 1967- (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Umeå Centre for Microbial Research (UCMR)
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- Kyriazis, Spyridon (author)
- Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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- Tsoukleris, Dimitrios S. (author)
- Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece; NanoViis Company, Athens, Greece
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- Tsilibary, Effie-Photini C (author)
- Department of Neuroscience, University of Minnesota, MN, Minneapolis, United States
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- Gazouli, Maria (author)
- Department of Basic Medical Sciences, Laboratory of Biology, Faculty of Medicine, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece
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- Pavlatou, Evangelia A. (author)
- Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece; vgorg@med.uoa.gr pavlatou@chemeng.ntua.gr
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- Gorgoulis, Vassilis G. (author)
- Biomedical Research Foundation Academy of Athens, Athens, Greece; Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; vgorg@med.uoa.gr pavlatou@chemeng.ntua.gr; Faculty of Biology, Medicine and Health Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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(creator_code:org_t)
- 2021-05-15
- 2021
- English.
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In: Cancer Genomics & Proteomics. - : Anticancer Research USA Inc.. - 1109-6535 .- 1790-6245. ; 18:3, s. 425-439
- Related links:
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https://cgp.iiarjour...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- BACKGROUND/AIM: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential.MATERIALS AND METHODS: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection.RESULTS AND CONCLUSION: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- anticancer properties
- apoptosis
- cytotoxicity
- Nanomedicine
- nanostructured titanium dioxide
- photocatalysis
- silver-modified titanium dioxide
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lagopati, Nefeli
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Kotsinas, Athana ...
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Veroutis, Dimitr ...
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Evangelou, Konst ...
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Papaspyropoulos, ...
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Arfanis, Michali ...
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Falaras, Polycar ...
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Kitsiou, Paraske ...
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Pateras, Ioannis
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Bergonzini, Anna
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Frisan, Teresa, ...
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Kyriazis, Spyrid ...
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Tsoukleris, Dimi ...
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Tsilibary, Effie ...
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Gazouli, Maria
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Pavlatou, Evange ...
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Gorgoulis, Vassi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Genomics ...
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Umeå University