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Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer

Lagopati, Nefeli (author)
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece
Kotsinas, Athanassios (author)
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Veroutis, Dimitris (author)
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece
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Evangelou, Konstantinos (author)
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Papaspyropoulos, Angelos (author)
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation Academy of Athens, Athens, Greece
Arfanis, Michalis (author)
Institute of Nanoscience and Nanotechnology, Laboratory of Nanotechnology Processes for Solar Energy Conversion and Environmental Protection, National Centre for Scientific Research "Demokritos", Athens, Greece
Falaras, Polycarpos (author)
Institute of Nanoscience and Nanotechnology, Laboratory of Nanotechnology Processes for Solar Energy Conversion and Environmental Protection, National Centre for Scientific Research "Demokritos", Athens, Greece
Kitsiou, Paraskevi V. (author)
Institute of Biosciences and Applications, Laboratory of Biochemistry/Cell & Matrix Pathobiology, National Centre for Scientific Research "Demokritos", Athens, Greece
Pateras, Ioannis (author)
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Bergonzini, Anna (author)
Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
Frisan, Teresa, 1967- (author)
Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Umeå Centre for Microbial Research (UCMR)
Kyriazis, Spyridon (author)
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Tsoukleris, Dimitrios S. (author)
Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece; NanoViis Company, Athens, Greece
Tsilibary, Effie-Photini C (author)
Department of Neuroscience, University of Minnesota, MN, Minneapolis, United States
Gazouli, Maria (author)
Department of Basic Medical Sciences, Laboratory of Biology, Faculty of Medicine, School of Health Science, National and Kapodistrian University of Athens, Athens, Greece
Pavlatou, Evangelia A. (author)
Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens, Greece; vgorg@med.uoa.gr pavlatou@chemeng.ntua.gr
Gorgoulis, Vassilis G. (author)
Biomedical Research Foundation Academy of Athens, Athens, Greece; Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece; vgorg@med.uoa.gr pavlatou@chemeng.ntua.gr; Faculty of Biology, Medicine and Health Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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 (creator_code:org_t)
2021-05-15
2021
English.
In: Cancer Genomics & Proteomics. - : Anticancer Research USA Inc.. - 1109-6535 .- 1790-6245. ; 18:3, s. 425-439
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND/AIM: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential.MATERIALS AND METHODS: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection.RESULTS AND CONCLUSION: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

anticancer properties
apoptosis
cytotoxicity
Nanomedicine
nanostructured titanium dioxide
photocatalysis
silver-modified titanium dioxide

Publication and Content Type

ref (subject category)
art (subject category)

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