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Updated European As...
Updated European Association of Urology Guidelines on Renal Cell Carcinoma : Nivolumab plus Cabozantinib Joins Immune Checkpoint Inhibition Combination Therapies for Treatment-naïve Metastatic Clear-Cell Renal Cell Carcinoma
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- Bedke, Jens (author)
- University Hospital of Tubingen,German Cancer Research Centre
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- Albiges, Laurence (author)
- Institut Gustave Roussy
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- Capitanio, Umberto (author)
- San Raffaele Scientific Institute
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- Giles, Rachel H. (author)
- University Medical Center Utrecht
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- Hora, Milan (author)
- Charles University in Prague
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- Lam, Thomas B. (author)
- University of Aberdeen
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- Ljungberg, Börje, Professor, 1949- (author)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Marconi, Lorenzo (author)
- University Hospital of Coimbra
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- Klatte, Tobias (author)
- University of Cambridge,Royal Bournemouth Hospital
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- Volpe, Alessandro (author)
- University of Eastern Piedmont
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- Abu-Ghanem, Yasmin (author)
- Sheba Medical Center
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- Dabestani, Saeed (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
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- Fernández-Pello, Sergio (author)
- University Hospital Cabueñes
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- Hofmann, Fabian (author)
- Umeå University,Umeå universitet,Urologi och andrologi,Sunderby Sjukhus. Luleå, Sweden
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Kuusk, Teele (author)
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- Tahbaz, Rana (author)
- Elbe kliniken
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- Powles, Thomas (author)
- Queen Mary University
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- Bex, Axel (author)
- Antoni Van Leeuwenhoek Hospital
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 79:3, s. 339-342
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Longer follow-up and new trial data from phase 3 randomised controlled trials investigating immune checkpoint blockade (PD-1 or its ligand PD-L1) in advanced clear-cell renal cell carcinoma (RCC) have recently become available. The CheckMate 9ER trial demonstrated an improved progression-free survival (PFS) and overall survival (OS) benefit for the combination of cabozantinib plus nivolumab. A Keynote-426 update demonstrated an ongoing OS benefit for pembrolizumab plus axitinib in the intention-to-treat population, with a PFS benefit seen across all International Metastatic Database Consortium (IMDC) subgroups, while an update of CheckMate 214 confirmed the long-term benefit of ipilimumab plus nivolumab in IMDC intermediate and poor risk patients. The RCC Guidelines Panel continues to recommend these tyrosine kinase inhibitors + immunotherapy (IO) combination across IMDC risk groups in advanced first-line RCC and dual immunotherapy of ipilimumab and nivolumab in IMDC intermediate and poor risk. PATIENT SUMMARY: New data from trials of immune checkpoint inhibitors for advanced kidney cancer confirm a survival benefit with the combination of cabozantinib plus nivolumab and pembrolizumab plus axitinib and ipilimumab plus nivolumab. These combination therapies are recommended as first-line treatment for advanced kidney cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cabozantinib
- Clear cell
- First line
- Nivolumab
- Renal cell carcinoma
- Systemic therapy
- Treatment-naïve
- Cabozantinib
- Clear cell
- First line
- Nivolumab
- Renal cell carcinoma
- Systemic therapy
- Treatment-naïve
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Bedke, Jens
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Albiges, Laurenc ...
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Capitanio, Umber ...
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Giles, Rachel H.
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Hora, Milan
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Lam, Thomas B.
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Ljungberg, Börje ...
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Marconi, Lorenzo
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Klatte, Tobias
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Volpe, Alessandr ...
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Abu-Ghanem, Yasm ...
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Dabestani, Saeed
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Fernández-Pello, ...
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Hofmann, Fabian
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Kuusk, Teele
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Tahbaz, Rana
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Powles, Thomas
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Bex, Axel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Urology
- By the university
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Umeå University
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Lund University