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Nicotinamide provid...
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Tribble, James R.Karolinska Institutet
(författare)
Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Elsevier,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-184461
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184461URI
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https://doi.org/10.1016/j.redox.2021.101988DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146717086URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to NAD) on retinal ganglion cells (the affected neuron in glaucoma) in normal physiological conditions and across a range of glaucoma relevant insults including mitochondrial stress and axon degenerative insults. We demonstrate retinal ganglion cell somal, axonal, and dendritic neuroprotection by nicotinamide in rodent models which represent isolated ocular hypertensive, axon degenerative, and mitochondrial degenerative insults. We performed metabolomics enriched for small molecular weight metabolites for the retina, optic nerve, and superior colliculus which demonstrates that ocular hypertension induces widespread metabolic disruption, including consistent changes to α-ketoglutaric acid, creatine/creatinine, homocysteine, and glycerophosphocholine. This metabolic disruption is prevented by nicotinamide. Nicotinamide provides further neuroprotective effects by increasing oxidative phosphorylation, buffering and preventing metabolic stress, and increasing mitochondrial size and motility whilst simultaneously dampening action potential firing frequency. These data support continued determination of the utility of long-term nicotinamide treatment as a neuroprotective therapy for human glaucoma.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Otmani, AminKarolinska Institutet
(författare)
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Sun, ShanshanSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
(författare)
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Ellis, Sevannah A.University of Melbourne, The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
(författare)
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Cimaglia, GloriaDepartment of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden; School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
(författare)
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Vohra, RupaliDepartment of Veterinary and Animal Sciences, Pathobiological Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Drug Design and Pharmacology, Eye Translational Research Unit, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
(författare)
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Jöe, MelissaKarolinska Institutet
(författare)
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Lardner, EmmaDepartment of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden
(författare)
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Venkataraman, Abinaya P.Karolinska Institutet
(författare)
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Domínguez-Vicent, AlbertoKarolinska Institutet
(författare)
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Kokkali, EiriniSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
(författare)
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Rho, SeungsooSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
(författare)
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Jóhannesson, Gauti,1979-Umeå universitet,Oftalmiatrik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)gaijon02
(författare)
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Burgess, Robert W.Jackson Laboratory, ME, United States
(författare)
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Fuerst, Peter G.WWAMI Medical Education Program, University of Idaho, ID, Moscow, United States
(författare)
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Brautaset, RuneKarolinska Institutet
(författare)
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Kolko, MiriamDepartment of Drug Design and Pharmacology, Eye Translational Research Unit, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark
(författare)
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Morgan, James E.School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Eye Unit, University Hospital Wales, Cardiff, UK; School of Medicine, Cardiff University, Cardiff, UK
(författare)
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Crowston, Jonathan G.Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Centre for Vision Research, Neuroscience and Behavioural Disorders, Duke-NUS, Singapore, Singapore
(författare)
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Votruba, MarcelaSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Eye Unit, University Hospital Wales, Cardiff, UK
(författare)
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Williams, Pete A.Karolinska Institutet
(författare)
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Karolinska InstitutetSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Redox Biology: Elsevier432213-2317
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Till lärosätets databas
- Av författaren/redakt...
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Tribble, James R ...
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Otmani, Amin
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Sun, Shanshan
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Ellis, Sevannah ...
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Cimaglia, Gloria
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Vohra, Rupali
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visa fler...
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Jöe, Melissa
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Lardner, Emma
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Venkataraman, Ab ...
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Domínguez-Vicent ...
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Kokkali, Eirini
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Rho, Seungsoo
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Jóhannesson, Gau ...
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Burgess, Robert ...
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Fuerst, Peter G.
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Brautaset, Rune
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Kolko, Miriam
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Morgan, James E.
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Crowston, Jonath ...
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Votruba, Marcela
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Williams, Pete A ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oftalmologi
- Artiklar i publikationen
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Redox Biology
- Av lärosätet
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Umeå universitet
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Karolinska Institutet