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Genetically predict...
Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent : a Mendelian randomization study
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- Tsilidis, Konstantinos K. (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Papadimitriou, Nikos (författare)
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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- Dimou, Niki (författare)
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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- Gill, Dipender (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Lewis, Sarah J. (författare)
- Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Martin, Richard M. (författare)
- Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; University Hospitals Bristol National Health Service Foundation Trust National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol, Bristol, United Kingdom
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- Murphy, Neil (författare)
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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- Markozannes, Georgios (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Zuber, Verena (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Medical Research Council Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
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- Cross, Amanda J. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Burrows, Kimberley (författare)
- Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Lopez, David S. (författare)
- Department of Preventive Medicine and Community Health, University of Texas Medical Branch, TX, Galveston, United States
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- Key, Timothy J. (författare)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Travis, Ruth C. (författare)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Perez-Cornago, Aurora (författare)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Hunter, David J. (författare)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- van Duijnhoven, Fränzel J B (författare)
- Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States
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- Arndt, Volker (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States
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- Bézieau, Stéphane (författare)
- Medical Genetics Service, University Hospital Center (CHU) Nantes, Nantes, France
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- Bishop, D Timothy (författare)
- Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
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- Boehm, Juergen (författare)
- Huntsman Cancer Institute, University of Utah, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Burnett-Hartman, Andrea (författare)
- Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
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- Campbell, Peter T. (författare)
- Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, United States
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- Casey, Graham (författare)
- Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
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- Castellví-Bel, Sergi (författare)
- Gastroenterology Department, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Biomedical Research Network Center for Liver and Digestive Diseases (CIBEREHD), University of Barcelona, Barcelona, Spain
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- Chan, Andrew T. (författare)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany
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- de la Chapelle, Albert (författare)
- Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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- Figueiredo, Jane C. (författare)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
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- Gallinger, Steven J. (författare)
- Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
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- Giles, Graham G. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Goodman, Phyllis J. (författare)
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
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- Gsur, Andrea (författare)
- Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
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- Hampe, Jochen (författare)
- Department of Medicine I, University Hospital Dresden, Dresden University of Technology (TU Dresden), Dresden, Germany
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- Hampel, Heather (författare)
- Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
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- Keku, Temitope O. (författare)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, United States
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- Kweon, Sun-Seog (författare)
- Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea
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- Larsson, Susanna C. (författare)
- Karolinska Institutet
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- Le Marchand, Loic (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- Li, Christopher I. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
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- Li, Li (författare)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Lindblom, Annika (författare)
- Karolinska Institutet
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- Martín, Vicente (författare)
- CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Biomedicine Institute (IBIOMED), University of León, León, Spain
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- Milne, Roger L. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Moreno, Victor (författare)
- CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
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- Nan, Hongmei (författare)
- Department of Epidemiology, Richard M Fairbanks School of Public Health, Indiana University, IN, Indianapolis, United States; IU Melvin and Bren Simon Cancer Center, Indiana University, IN, Indianapolis, United States
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- Nassir, Rami (författare)
- Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; School of Public Health, University of Washington, Seattle, WA, USA
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- Offit, Kenneth (författare)
- Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, NY, United States; Department of Medicine, Weill Cornell Medical College, NY, NY, United States
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- Pharoah, Paul D P (författare)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Platz, Elizabeth A. (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- Potter, John D. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Centre for Public Health Research, Massey University, Wellington, New Zealand
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- Qi, Lihong (författare)
- Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA, USA
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- Rennert, Gad (författare)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
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- Sakoda, Lori C. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA
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- Schafmayer, Clemens (författare)
- Department of General Surgery, University Hospital Rostock, Rostock, Germany
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- Slattery, Martha L. (författare)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Snetselaar, Linda (författare)
- Department of Epidemiology, University of Iowa College of Public Health, IA, Iowa City, United States
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- Schenk, Jeanette (författare)
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
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- Thibodeau, Stephen N. (författare)
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- Ulrich, Cornelia M. (författare)
- Huntsman Cancer Institute, University of Utah, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- van Guelpen, Bethany (författare)
- Umeå universitet,Onkologi
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Onkologi
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- Visvanathan, Kala (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- Vodickova, Ludmila (författare)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Wang, Hansong (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- White, Emily (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Woods, Michael O. (författare)
- Discipline of Genetics, Memorial University of Newfoundland, St. John's ,Newfoundland, Canada
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- Wu, Anna H. (författare)
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
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- Zheng, Wei (författare)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States
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- Bueno-de-Mesquita, Bas (författare)
- Formerly, Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
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- Boutron-Ruault, Marie-Christine (författare)
- Faculty of Medicine, CESP, University of Paris-Sud, Faculty of Medicine UVSQ, INSERM, University of Paris-Saclay, Villejuif, France; Centre for Research in Epidemiology and Population Health (CESP), Gustave Roussy, Villejuif, France
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- Hughes, David J. (författare)
- Cancer Biology and Therapeutics Group, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
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- Jakszyn, Paula (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology- Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Blanquerna Faculty of Health Sciences, Ramon Llull University, Barcelona, Spain
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- Kühn, Tilman (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy
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- Riboli, Elio (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Giovannucci, Edward L. (författare)
- Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Nutrition, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States
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- Banbury, Barbara L. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
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- Gruber, Stephen B. (författare)
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA
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- Gunter, Marc J. (författare)
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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(creator_code:org_t)
- Oxford University Press, 2021
- 2021
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 113:6, s. 1490-1502
- Relaterad länk:
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https://doi.org/10.1...
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https://www.scienced...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.OBJECTIVES: To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR). METHODS: Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.RESULTS: Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetically predicted concentrations of β-carotene, calcium, copper, folate, magnesium, phosphorus, and vitamin B-6 were not associated with disease risk.CONCLUSIONS: These results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- colorectal cancer
- genes
- Mendelian randomization
- nutrition
- supplements
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Tsilidis, Konsta ...
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Papadimitriou, N ...
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Dimou, Niki
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Gill, Dipender
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Lewis, Sarah J.
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Martin, Richard ...
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Murphy, Neil
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Markozannes, Geo ...
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Zuber, Verena
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Cross, Amanda J.
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Burrows, Kimberl ...
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Lopez, David S.
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Key, Timothy J.
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Travis, Ruth C.
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Perez-Cornago, A ...
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Hunter, David J.
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van Duijnhoven, ...
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Albanes, Demetri ...
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Arndt, Volker
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Berndt, Sonja I.
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Bézieau, Stéphan ...
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Bishop, D Timoth ...
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Boehm, Juergen
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Brenner, Hermann
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Burnett-Hartman, ...
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Campbell, Peter ...
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Casey, Graham
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Castellví-Bel, S ...
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Chan, Andrew T.
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Chang-Claude, Je ...
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de la Chapelle, ...
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Figueiredo, Jane ...
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Gallinger, Steve ...
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Giles, Graham G.
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Goodman, Phyllis ...
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Gsur, Andrea
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Hampe, Jochen
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Hampel, Heather
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Hoffmeister, Mic ...
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Jenkins, Mark A.
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Keku, Temitope O ...
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Kweon, Sun-Seog
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Larsson, Susanna ...
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Le Marchand, Loi ...
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Li, Christopher ...
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Li, Li
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Lindblom, Annika
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Martín, Vicente
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Milne, Roger L.
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Moreno, Victor
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Nan, Hongmei
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Nassir, Rami
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Newcomb, Polly A ...
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Offit, Kenneth
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Pharoah, Paul D ...
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Platz, Elizabeth ...
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Potter, John D.
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Qi, Lihong
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Rennert, Gad
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Sakoda, Lori C.
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Schafmayer, Clem ...
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Slattery, Martha ...
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Snetselaar, Lind ...
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Schenk, Jeanette
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Thibodeau, Steph ...
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Ulrich, Cornelia ...
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van Guelpen, Bet ...
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Harlid, Sophia, ...
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Visvanathan, Kal ...
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Vodickova, Ludmi ...
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Wang, Hansong
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White, Emily
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Wolk, Alicja
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Woods, Michael O ...
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Wu, Anna H.
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Zheng, Wei
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Bueno-de-Mesquit ...
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Boutron-Ruault, ...
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Hughes, David J.
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Jakszyn, Paula
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Kühn, Tilman
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Palli, Domenico
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Riboli, Elio
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Giovannucci, Edw ...
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Banbury, Barbara ...
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Gruber, Stephen ...
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Peters, Ulrike
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Gunter, Marc J.
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