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Escherichia coli ca...
Escherichia coli causing recurrent urinary tract infections: Comparison to non-recurrent isolates and genomic adaptation in recurrent infections
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- Nielsen, Karen Leth (author)
- Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
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- Stegger, Marc (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark
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- Kiil, Kristoffer (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark
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- Lilje, Berit (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark
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- Ejrnæs, Karen (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark; Department of Pathology, Herlev Hospital, Herlev, Denmark
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- Leihof, Rikke Fleron (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark; Analytical Development, Novo Nordisk, Måløv, Denmark
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- Skjøt-Rasmussen, Line (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark; Animal Health Innovation, Chr. Hansen, Hørsholm, Denmark
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- Godfrey, Paul (author)
- Genome Sequencing and Analysis Program, Institute of Technology, Broad Institute of Harvard and Massachusetts, MA, Cambridge, United States
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- Monsen, Tor J. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Ferry, Sven A. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Hammerum, Anette M. (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark
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- Frimodt-Møller, Niels (author)
- Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
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(creator_code:org_t)
- 2021-06-30
- 2021
- English.
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In: Microorganisms. - : MDPI. - 2076-2607. ; 9:7
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Abstract
Subject headings
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- Recurrent urinary tract infection (rUTI) remains a major problem for many women and therefore the pursuit for genomic and phenotypic traits which could define rUTI has been ongoing. The present study applied a genomic approach to investigate recurrent urinary tract infections by comparative analyses of recurrent and non-recurrent Escherichia coli isolates from general practice. From whole-genome sequencing data, phylogenetic clustering and genomic traits were studied on a collection of isolates which caused recurrent infection compared to non-recurrent isolates. In addition, genomic variation between the 1st and following infection was studied on a subset of the isolates. Evidence of limited adaptation between the recurrent infections based on single nucleotide polymorphism analyses with a range of 0–13 non-synonymous single nucleotide polymorphisms (SNPs) between the paired isolates. This included an overrepresentation of SNPs in metabolism genes. We identified several genes which were more common in rUTI isolates, including nine fimbrial genes, however, not significantly after false-discovery rate. Finally, the results show that recurrent isolates of the present dataset are not distinctive by variation in the core genome, and thus, did not cluster distinct from non-rUTI isolates in a SNP phylogeny.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Adaptation
- Escherichia coli
- Genomics
- Mobilome
- Single nucleotide polymorphisms
- Urinary tract infection
- Whole-genome sequencing
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nielsen, Karen L ...
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Stegger, Marc
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Kiil, Kristoffer
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Lilje, Berit
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Ejrnæs, Karen
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Leihof, Rikke Fl ...
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show more...
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Skjøt-Rasmussen, ...
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Godfrey, Paul
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Monsen, Tor J.
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Ferry, Sven A.
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Hammerum, Anette ...
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Frimodt-Møller, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
- Articles in the publication
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Microorganisms
- By the university
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Umeå University