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The genetic organiz...
The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change
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- Fjell, Anders M. (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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- Grydeland, Håkon (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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- Wang, Yunpeng (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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- Amlien, Inge (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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- Bartrés-Faz, David (författare)
- Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
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- Brandmaier, Andreas M. (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom
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- Düzel, Sandra (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Elman, Jeremy (författare)
- Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
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- Franz, Carol (författare)
- Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
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- Håberg, Asta K. (författare)
- Department of Medical Imaging, St. Olav's Hospital, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
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- Kietzmann, Tim C. (författare)
- MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands
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- Kievit, Rogier A. (författare)
- MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom
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- Kremen, William S. (författare)
- Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, United States; Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
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- Krogsrud, Stine K. (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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- Kühn, Simone (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany
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- Lindenberger, Ulman (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom
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- Macià, Didac (författare)
- Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
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- Mowinckel, Athanasia M. (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Panizzon, Matthew S. (författare)
- Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
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- Solé-Padullés, Cristina (författare)
- Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
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- Sørensen, Øystein (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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- Westerhausen, René (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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- Walhovd, Kristine B. (författare)
- Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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(creator_code:org_t)
- eLife Sciences Publications Ltd, 2021
- 2021
- Engelska.
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
- Relaterad länk:
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https://doi.org/10.7...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single nucleotide polymorphisms-based analyses of 38127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Aging
- Brain
- Development
- Genetics
- Hippocampus
- lifespan
- Subcortex
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- Av författaren/redakt...
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Fjell, Anders M.
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Grydeland, Håkon
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Wang, Yunpeng
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Amlien, Inge
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Bartrés-Faz, Dav ...
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Brandmaier, Andr ...
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visa fler...
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Düzel, Sandra
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Elman, Jeremy
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Franz, Carol
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Håberg, Asta K.
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Kietzmann, Tim C ...
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Kievit, Rogier A ...
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Kremen, William ...
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Krogsrud, Stine ...
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Kühn, Simone
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Lindenberger, Ul ...
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Macià, Didac
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Mowinckel, Athan ...
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Nyberg, Lars, 19 ...
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Panizzon, Matthe ...
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Solé-Padullés, C ...
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Sørensen, Øystei ...
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Westerhausen, Re ...
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Walhovd, Kristin ...
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