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  • Dagnino, SoniaMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)

Prospective identification of elevated circulating CDCP1 in patients years before onset of lung cancer

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • American Association for Cancer Research,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-185886
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185886URI
  • https://doi.org/10.1158/0008-5472.CAN-20-3454DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Increasing evidence points to a role for inflammation in lung carcinogenesis. A small number of circulating inflammatory proteins have been identified as showing elevated levels prior to lung cancer diagnosis, indicating the potential for prospective circulating protein concentration as a marker of early carcinogenesis. To identify novel markers of lung cancer risk, we measured a panel of 92 circulating inflammatory proteins in 648 prediagnostic blood samples from two prospective cohorts in Italy and Norway (women only). To preserve the comparability of results and protect against confounding factors, the main statistical analyses were conducted in women from both studies, with replication sought in men (Italian participants). Univariate and penalized regression models revealed for the first time higher blood levels of CDCP1 protein in cases that went on to develop lung cancer compared with controls, irrespective of time to diagnosis, smoking habits, and gender. This association was validated in an additional 450 samples. Associations were stronger for future cases of adenocarcinoma where CDCP1 showed better explanatory performance. Integrative analyses combining gene expression and protein levels of CDCP1 measured in the same individuals suggested a link between CDCP1 and the expression of transcripts of LRRN3 and SEM1. Enrichment analyses indicated a potential role for CDCP1 in pathways related to cell adhesion and mobility, such as the WNT/β-catenin pathway. Overall, this study identifies lung cancer–related dysregulation of CDCP1 expression years before diagnosis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bodinier, BarbaraMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Guida, FlorenceInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Smith-Byrne, KarlInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Petrovic, DusanMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Epidemiology and Health Systems (DESS), University Center for General Medicine and Public Health (UNISANTE), Lausanne, Switzerland; Department and Division of Primary Care Medicine, University Hospital of Geneva, Geneva, Switzerland (författare)
  • Whitaker, Matthew D.MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Nøst, Therese HaugdahlDepartment of Community Medicine, UiT- The Arctic University of Norway, Tromsø, Norway (författare)
  • Agnoli, ClaudiaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (författare)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy (författare)
  • Sacerdote, CarlottaUnit of Cancer Epidemiology, Citta della Salute e della Scienza University-Hospital, Turin, Italy (författare)
  • Panico, SalvatoreDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy (författare)
  • Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority (ASP) Ragusa, Italy (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany (författare)
  • Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (författare)
  • Keski-Rahkonen, PekkaInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Scalbert, AugustinInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Vineis, PaoloMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy (författare)
  • Johansson, MattiasInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Sandanger, Torkjel M.Department of Community Medicine, UiT- The Arctic University of Norway, Tromsø, Norway (författare)
  • Vermeulen, Roel C.H.MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (författare)
  • Chadeau-Hyam, MarcMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (författare)
  • MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United KingdomInternational Agency for Research on Cancer (IARC), Lyon, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Research: American Association for Cancer Research81:13, s. 3738-37480008-54721538-7445

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