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Alcohol intake and ...
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Di Castelnuovo, AugustoMediterranea Cardiocentro, Napoli, Italy
(författare)
Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2021-07-08
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John Wiley & Sons,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-186186
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186186URI
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https://doi.org/10.1111/add.15593DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Aim: To test the association of alcohol consumption with total and cause-specific mortality risk. Design: Prospective observational multi-centre population-based study.Setting: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project.Participants: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).Measurements: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality.Findings: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7–14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7–20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10–35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.Conclusions: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Costanzo, SimonaDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(författare)
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Bonaccio, MarialauraDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(författare)
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McElduff, PatrickUniversity of Newcastle & Hunter Medical Research Institute, Australia
(författare)
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Linneberg, AllanCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Salomaa, VeikkoFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Männistö, SatuFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Moitry, MarieDepartment of Public Health, University Hospital of Strasbourg and Department of Epidemiology and Public Health, University of Strasbourg, France
(författare)
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Ferrières, JeanDepartment of Cardiology and INSERM UMR 1295, Toulouse University Hospital, Toulouse, France
(författare)
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Dallongeville, JeanUniversity of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France
(författare)
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Thorand, BarbaraHelmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
(författare)
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Brenner, HermannDivision of Clinical Epidemiology and Aging Research and Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany
(författare)
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Ferrario, MarcoResearch Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
(författare)
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Veronesi, GiovanniResearch Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
(författare)
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Pettenuzzo, EmanuelaResearch Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
(författare)
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Tamosiunas, AbdonasLithuanian University of Health Sciences, Kaunas, Lithuania
(författare)
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Njølstad, IngerDepartment of community Medicine, University of Tromsø - the Arctic University of Norway, Norway
(författare)
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Drygas, WojciechDepartment of Epidemiology CVD Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland
(författare)
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Nikitin, YuriThe Institute of Internal and Preventive Medicine, Novosibirsk, Russian Federation
(författare)
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Söderberg, StefanUmeå universitet,Avdelningen för medicin(Swepub:umu)stso0001
(författare)
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Kee, FrankCentre for Public Health, Queens University of Belfast, Belfast, United Kingdom
(författare)
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Grassi, GuidoClinica Medica, Università Milano-Bicocca, Milano, Italy
(författare)
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Westermann, DirkClinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
(författare)
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Schrage, BenediktClinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
(författare)
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Dabboura, SalimClinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
(författare)
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Zeller, TanjaClinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
(författare)
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Kuulasmaa, KariFinnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Blankenberg, StefanClinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
(författare)
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Donati, Maria BenedettaDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(författare)
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de Gaetano, GiovanniDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(författare)
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Iacoviello, LiciaDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
(författare)
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Mediterranea Cardiocentro, Napoli, ItalyDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Addiction: John Wiley & Sons117:2, s. 312-3250965-21401360-0443
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Till lärosätets databas
- Av författaren/redakt...
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Di Castelnuovo, ...
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Costanzo, Simona
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Bonaccio, Marial ...
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McElduff, Patric ...
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Linneberg, Allan
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Salomaa, Veikko
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visa fler...
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Männistö, Satu
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Moitry, Marie
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Ferrières, Jean
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Dallongeville, J ...
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Thorand, Barbara
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Brenner, Hermann
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Ferrario, Marco
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Veronesi, Giovan ...
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Pettenuzzo, Eman ...
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Tamosiunas, Abdo ...
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Njølstad, Inger
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Drygas, Wojciech
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Nikitin, Yuri
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Söderberg, Stefa ...
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Kee, Frank
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Grassi, Guido
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Westermann, Dirk
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Schrage, Benedik ...
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Dabboura, Salim
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Zeller, Tanja
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Kuulasmaa, Kari
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Blankenberg, Ste ...
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Donati, Maria Be ...
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de Gaetano, Giov ...
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Iacoviello, Lici ...
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