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Enhancer-derived lo...
Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis
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- Thean, Lai Fun (författare)
- Department of Colorectal Surgery, Singapore General Hospital, Academia, Level 9, Discovery Tower, 20 College Road, Singapore, Singapore
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- Blöcker, Christopher (författare)
- Umeå universitet,Institutionen för fysik
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- Li, Hui Hua (författare)
- Health Service Research Unit, Singapore General Hospital, Singapore, Singapore
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- Lo, Michelle (författare)
- Department of Colorectal Surgery, Singapore General Hospital, Academia, Level 9, Discovery Tower, 20 College Road, Singapore, Singapore
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- Wong, Michelle (författare)
- Department of Colorectal Surgery, Singapore General Hospital, Academia, Level 9, Discovery Tower, 20 College Road, Singapore, Singapore
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- Tang, Choong Leong (författare)
- Department of Colorectal Surgery, Singapore General Hospital, Academia, Level 9, Discovery Tower, 20 College Road, Singapore, Singapore
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- Tan, Emile K. W. (författare)
- Department of Colorectal Surgery, Singapore General Hospital, Academia, Level 9, Discovery Tower, 20 College Road, Singapore, Singapore
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- Rozen, Steven G. (författare)
- Duke-NUS Center for Computational Biology, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
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- Cheah, Peh Yean (författare)
- Department of Colorectal Surgery, Singapore General Hospital, Academia, Level 9, Discovery Tower, 20 College Road, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
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(creator_code:org_t)
- 2021-01-11
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Up-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript (CCAT) 1 and 2, was associated with worse prognosis in colorectal cancer (CRC). Nevertheless, their role in predicting metastasis in early-stage CRC is unclear. We measured the expression of CCAT1, CCAT2 and their oncotarget, c-Myc, in 150 matched mucosa-tumour samples of early-stage microsatellite-stable Chinese CRC patients with definitive metastasis status by multiplex real-time RT-PCR assay. Expression of CCAT1, CCAT2 and c-Myc were significantly up-regulated in the tumours compared to matched mucosa (p < 0.0001). The expression of c-Myc in the tumours was significantly correlated to time to metastasis [hazard ratio = 1.47 (1.10–1.97)] and the risk genotype (GG) of rs6983267, located within CCAT2. Expression of c-Myc and CCAT2 in the tumour were also significantly up-regulated in metastasis-positive compared to metastasis-negative patients (p = 0.009 and p = 0.04 respectively). Nevertheless, integrating the expression of CCAT1 and CCAT2 by the Random Forest classifier did not improve the predictive values of ColoMet19, the mRNA-based predictor for metastasis previously developed on the same series of tumours. The role of these two lncRNAs is probably mitigated via their oncotarget, c-Myc, which was not ranked high enough previously to be included in ColoMet19.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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