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Fractional anisotro...
Fractional anisotropy thresholding for deterministic tractography of the roots of the brachial plexus
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- Wade, Ryckie G. (författare)
- Academic Plastic Surgery Office, Department of Plastic and Reconstructive Surgery, Leeds General Infirmary, Leeds Teaching Hospitals Trust, Leeds, United Kingdom; Faculty of Medicine and Health Sciences, University of Leeds, Leeds, United Kingdom
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- Teh, Irvin (författare)
- Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom
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- Andersson, Gustav (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Handkirurgi
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- Yeh, Fang-Cheng (författare)
- Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, United States
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- Wiberg, Mikael (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Handkirurgi
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- Bourke, Gráinne (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Handkirurgi,Academic Plastic Surgery Office, Department of Plastic and Reconstructive Surgery, Leeds General Infirmary, Leeds Teaching Hospitals Trust, Leeds, United Kingdom; Faculty of Medicine and Health Sciences, University of Leeds, Leeds, United Kingdom
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(creator_code:org_t)
- 2021-01-08
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Diffusion tensor imaging (DTI) metrics, such as the fractional anisotropy (FA) and estimates of diffusivity are sensitive to the microstructure of peripheral nerves and may be displayed as tractograms. However, the ideal conditions for tractography of the roots of the brachial plexus are unclear, which represents the rationale for this study. Ten healthy adults were scanned using a Siemens Prisma (3T) and single-shot echo-planar imaging (b-value 0/1000 s/mm2, 64 directions, 2.5 mm3 with 4 averages; repeated in opposing phase encoding directions). Susceptibility correction and tractography were performed in DSI Studio by two independent raters. The effect of FA thresholding at increments of 0.01 (from 0.04 to 0.10) were tested. The mean FA varied between subjects by 2% (95% CI 1%, 3%). FA thresholds of 0.04, 0.05 and 0.06 all propagated 96% of tracts representing the roots; thresholding at 0.07 yielded 4% fewer tracts (p = 0.2), 0.08 yielded 11% fewer tracts (p = 0.008), 0.09 yielded 15% fewer tracts (p = 0.001) and 0.1 yielded 20% fewer tracts (p < 0.001). There was < 0.1% inter-rater variability in the measured FA and 99% agreement for tractography (κ = 0.92, p < 0.001). The fractional anisotropy thresholds required to generate tractograms of the roots of the brachial plexus appears to be lower than those used in the brain. We provide estimates of the probability of generating true tracts for each spinal nerve root of the brachial plexus, at different fractional anisotropy thresholds.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
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