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An investigation of causal relationships between prediabetes and vascular complications

Mutie, Pascal M. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Pomares-Millan, Hugo (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Atabaki-Pasdar, Naeimeh (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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Jordan, Nina (author)
Regulatory Affairs Intelligence, Novo Nordisk A/S, Copenhagen, Denmark
Adams, Rachel (author)
Regulatory Affairs—Neuroscience and Cardiovascular Metabolism, Janssen, High Wycombe, United Kingdom,Janssen Inc., Canada
Daly, Nicole L. (author)
Regulatory Affairs—Neuroscience and Cardiovascular Metabolism, Janssen, High Wycombe, United Kingdom,Janssen Inc., Canada
Tajes, Juan Fernandes (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Giordano, Giuseppe N. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Franks, Paul W. (author)
Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för hållbar hälsa,Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital, Jan Waldenströms gata 35, Malmö, Sweden; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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 (creator_code:org_t)
2020-09-14
2020
English.
In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 11:1
Related links:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://www.nature.c...
http://dx.doi.org/10... (free)
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Prediabetes is a state of glycaemic dysregulation below the diagnostic threshold of type 2 diabetes (T2D). Globally, ~352 million people have prediabetes, of which 35–50% develop full-blown diabetes within five years. T2D and its complications are costly to treat, causing considerable morbidity and early mortality. Whether prediabetes is causally related to diabetes complications is unclear. Here we report a causal inference analysis investigating the effects of prediabetes in coronary artery disease, stroke and chronic kidney disease, complemented by a systematic review of relevant observational studies. Although the observational studies suggest that prediabetes is broadly associated with diabetes complications, the causal inference analysis revealed that prediabetes is only causally related with coronary artery disease, with no evidence of causal effects on other diabetes complications. In conclusion, prediabetes likely causes coronary artery disease and its prevention is likely to be most effective if initiated prior to the onset of diabetes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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