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Sökning: WFRF:(Hua Y) > (2020-2024) > Lysosomal lipoprote...

Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

Fischer, Alexander W. (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United States
Jaeckstein, Michelle Y. (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Gottschling, Kristina (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Heine, Markus (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Sass, Frederike (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Mangels, Nils (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Schlein, Christian (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Worthmann, Anna (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Bruns, Oliver T. (författare)
Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany
Yuan, Yucheng (författare)
Department of Chemistry, Brown University, RI, Providence, United States
Zhu, Hua (författare)
Department of Chemistry, Brown University, RI, Providence, United States
Chen, Ou (författare)
Department of Chemistry, Brown University, RI, Providence, United States
Ittrich, Harald (författare)
Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Nilsson, Stefan K., 1979- (författare)
Umeå universitet,Fysiologisk kemi
Stefanicka, Patrik (författare)
Department of Otorhinolaryngology – Head and Neck Surgery, Comenius University, Bratislava, Slovakia
Ukropec, Jozef (författare)
Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia
Balaz, Miroslav (författare)
Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
Dong, Hua (författare)
Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
Sun, Wenfei (författare)
Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
Reimer, Rudolf (författare)
Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
Scheja, Ludger (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Heeren, Joerg (författare)
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United States Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (creator_code:org_t)
Elsevier, 2021
2021
Engelska.
Ingår i: Cell Metabolism. - : Elsevier. - 1550-4131 .- 1932-7420. ; 33:3, s. 547-564.e7
Relaterad länk:
http://www.cell.com/...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.

Ämnesord

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

angiogenesis
beige adipocytes
brown adipose tissue
endothelial cells
hypoxia-inducible factor 1α
lipoproteins
lysosomal acid lipase
thermogenesis
triglycerides
white adipose tissue

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