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Lysosomal lipoprote...
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Fischer, Alexander W.Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United States
(författare)
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Elsevier,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-186316
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186316URI
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https://doi.org/10.1016/j.cmet.2020.12.001DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jaeckstein, Michelle Y.Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Gottschling, KristinaDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Heine, MarkusDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Sass, FrederikeDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Mangels, NilsDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Schlein, ChristianDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Worthmann, AnnaDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Bruns, Oliver T.Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany
(författare)
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Yuan, YuchengDepartment of Chemistry, Brown University, RI, Providence, United States
(författare)
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Zhu, HuaDepartment of Chemistry, Brown University, RI, Providence, United States
(författare)
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Chen, OuDepartment of Chemistry, Brown University, RI, Providence, United States
(författare)
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Ittrich, HaraldDepartment of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Nilsson, Stefan K.,1979-Umeå universitet,Fysiologisk kemi(Swepub:umu)nist6501
(författare)
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Stefanicka, PatrikDepartment of Otorhinolaryngology – Head and Neck Surgery, Comenius University, Bratislava, Slovakia
(författare)
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Ukropec, JozefInstitute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia
(författare)
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Balaz, MiroslavInstitute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
(författare)
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Dong, HuaInstitute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
(författare)
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Sun, WenfeiInstitute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
(författare)
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Reimer, RudolfHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
(författare)
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Scheja, LudgerDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Heeren, JoergDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United StatesDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cell Metabolism: Elsevier33:3, s. 547-564.e71550-41311932-7420
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Till lärosätets databas
- Av författaren/redakt...
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Fischer, Alexand ...
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Jaeckstein, Mich ...
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Gottschling, Kri ...
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Heine, Markus
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Sass, Frederike
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Mangels, Nils
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visa fler...
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Schlein, Christi ...
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Worthmann, Anna
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Bruns, Oliver T.
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Yuan, Yucheng
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Zhu, Hua
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Chen, Ou
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Ittrich, Harald
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Nilsson, Stefan ...
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Stefanicka, Patr ...
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Ukropec, Jozef
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Balaz, Miroslav
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Dong, Hua
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Sun, Wenfei
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Reimer, Rudolf
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Scheja, Ludger
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Heeren, Joerg
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