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  • Fischer, Alexander W.Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United States (författare)

Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-186316
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186316URI
  • https://doi.org/10.1016/j.cmet.2020.12.001DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jaeckstein, Michelle Y.Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Gottschling, KristinaDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Heine, MarkusDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Sass, FrederikeDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Mangels, NilsDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Schlein, ChristianDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Worthmann, AnnaDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Bruns, Oliver T.Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany (författare)
  • Yuan, YuchengDepartment of Chemistry, Brown University, RI, Providence, United States (författare)
  • Zhu, HuaDepartment of Chemistry, Brown University, RI, Providence, United States (författare)
  • Chen, OuDepartment of Chemistry, Brown University, RI, Providence, United States (författare)
  • Ittrich, HaraldDepartment of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Nilsson, Stefan K.,1979-Umeå universitet,Fysiologisk kemi(Swepub:umu)nist6501 (författare)
  • Stefanicka, PatrikDepartment of Otorhinolaryngology – Head and Neck Surgery, Comenius University, Bratislava, Slovakia (författare)
  • Ukropec, JozefInstitute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia (författare)
  • Balaz, MiroslavInstitute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland (författare)
  • Dong, HuaInstitute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland (författare)
  • Sun, WenfeiInstitute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland (författare)
  • Reimer, RudolfHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany (författare)
  • Scheja, LudgerDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Heeren, JoergDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United StatesDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cell Metabolism: Elsevier33:3, s. 547-564.e71550-41311932-7420

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