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Lysosomal lipoprote...
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
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- Fischer, Alexander W. (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United States
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- Jaeckstein, Michelle Y. (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Gottschling, Kristina (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Heine, Markus (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Sass, Frederike (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Mangels, Nils (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Schlein, Christian (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Worthmann, Anna (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Bruns, Oliver T. (författare)
- Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany
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- Yuan, Yucheng (författare)
- Department of Chemistry, Brown University, RI, Providence, United States
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- Zhu, Hua (författare)
- Department of Chemistry, Brown University, RI, Providence, United States
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- Chen, Ou (författare)
- Department of Chemistry, Brown University, RI, Providence, United States
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- Ittrich, Harald (författare)
- Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Nilsson, Stefan K., 1979- (författare)
- Umeå universitet,Fysiologisk kemi
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- Stefanicka, Patrik (författare)
- Department of Otorhinolaryngology – Head and Neck Surgery, Comenius University, Bratislava, Slovakia
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- Ukropec, Jozef (författare)
- Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia
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- Balaz, Miroslav (författare)
- Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
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- Dong, Hua (författare)
- Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
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- Sun, Wenfei (författare)
- Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland
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- Reimer, Rudolf (författare)
- Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
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- Scheja, Ludger (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Heeren, Joerg (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United States Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Cell Metabolism. - : Elsevier. - 1550-4131 .- 1932-7420. ; 33:3, s. 547-564.e7
- Relaterad länk:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- angiogenesis
- beige adipocytes
- brown adipose tissue
- endothelial cells
- hypoxia-inducible factor 1α
- lipoproteins
- lysosomal acid lipase
- thermogenesis
- triglycerides
- white adipose tissue
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- Av författaren/redakt...
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Fischer, Alexand ...
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Jaeckstein, Mich ...
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Gottschling, Kri ...
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Heine, Markus
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Sass, Frederike
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Mangels, Nils
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visa fler...
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Schlein, Christi ...
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Worthmann, Anna
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Bruns, Oliver T.
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Yuan, Yucheng
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Zhu, Hua
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Chen, Ou
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Ittrich, Harald
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Nilsson, Stefan ...
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Stefanicka, Patr ...
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Ukropec, Jozef
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Balaz, Miroslav
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Dong, Hua
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Sun, Wenfei
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Reimer, Rudolf
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Scheja, Ludger
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Heeren, Joerg
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visa färre...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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Cell Metabolism
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Umeå universitet