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  • Giorgi Rossi, PaoloAzienda Unità Sanitaria Locale—IRCCS di Reggio Emilia, Reggio Emilia, Italy (författare)

Recommendations from the European Commission Initiative on Breast Cancer for multigene testing to guide the use of adjuvant chemotherapy in patients with early breast cancer, hormone receptor positive, HER-2 negative

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-02-18
  • Springer,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-186339
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186339URI
  • https://doi.org/10.1038/s41416-020-01247-zDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Background: Predicting the risk of recurrence and response to chemotherapy in women with early breast cancer is crucial to optimise adjuvant treatment. Despite the common practice of using multigene tests to predict recurrence, existing recommendations are inconsistent. Our aim was to formulate healthcare recommendations for the question “Should multigene tests be used in women who have early invasive breast cancer, hormone receptor-positive, HER2-negative, to guide the use of adjuvant chemotherapy?”Methods: The European Commission Initiative on Breast Cancer (ECIBC) Guidelines Development Group (GDG), a multidisciplinary guideline panel including experts and three patients, developed recommendations informed by systematic reviews of the evidence. Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision frameworks were used. Four multigene tests were evaluated: the 21-gene recurrence score (21-RS), the 70-gene signature (70-GS), the PAM50 risk of recurrence score (PAM50-RORS), and the 12-gene molecular score (12-MS).Results: Five studies (2 marker-based design RCTs, two treatment interaction design RCTs and 1 pooled individual data analysis from observational studies) were included; no eligible studies on PAM50-RORS or 12-MS were identified and the GDG did not formulate recommendations for these tests.Conclusions: The ECIBC GDG suggests the use of the 21-RS for lymph node-negative women (conditional recommendation, very low certainty of evidence), recognising that benefits are probably larger in women at high risk of recurrence based on clinical characteristics. The ECIBC GDG suggests the use of the 70-GS for women at high clinical risk (conditional recommendation, low certainty of evidence), and recommends not using 70-GS in women at low clinical risk (strong recommendation, low certainty of evidence).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lebeau, AnnetteDepartment of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Canelo-Aybar, CarlosIberoamerican Cochrane Center, Biomedical Research Institute (IIB Sant Pau-CIBERESP), Barcelona, Spain; Department of Paediatrics, Obstetrics and Gynaecology, Preventive Medicine, and Public Health, PhD Programme in Methodology of Biomedical Research and Public Health, Universitat Autònoma de Barcelona, Bellaterra, Spain (författare)
  • Saz-Parkinson, ZuleikaEuropean Commission, Joint Research Centre (JRC), Ispra, Italy; Instituto de Salud Carlos III, Health Technology Assessment Agency, Avenida Monforte de Lemos 5, Madrid, Spain (författare)
  • Quinn, CecilySt. Vincent’s University Hospital, Dublin, Ireland (författare)
  • Langendam, MirandaDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Institute, Amsterdam, Netherlands (författare)
  • Mcgarrigle, HelenCardiff and Vale UHB - General Surgery, Cardiff, United Kingdom (författare)
  • Warman, SueHavyatt Lodge, Havyatt Road, North Somerset, Langford, United Kingdom (författare)
  • Rigau, DavidIberoamerican Cochrane Center, Biomedical Research Institute (IIB Sant Pau-CIBERESP), Barcelona, Spain (författare)
  • Alonso-Coello, PabloIberoamerican Cochrane Center, Biomedical Research Institute (IIB Sant Pau-CIBERESP), Barcelona, Spain (författare)
  • Broeders, MireilleDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, Netherlands; Dutch Expert Centre for Screening, Nijmegen, Netherlands (författare)
  • Graewingholt, AxelRadiologie am Theater, NRW, Paderborn, Germany (författare)
  • Posso, MargaritaIberoamerican Cochrane Center, Biomedical Research Institute (IIB Sant Pau-CIBERESP), Barcelona, Spain; Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain (författare)
  • Duffy, StephenCentre for Cancer Prevention, Queen Mary University of London, Charterhouse Square, London, United Kingdom (författare)
  • Schünemann, Holger J.Michael G. DeGroote Cochrane Canada and McGRADE Centres; Department of Health Research Methods, Evidence and Impact, McMaster University Health Sciences Centre, ON, Hamilton, Canada (författare)
  • Autelitano, MariangelaCancer Registry of Milan, Milan, Italy (författare)
  • Borisch, BettinaInstitute of Global Health. University of Geneva, Geneva, Switzerland (författare)
  • Castells, XavierIMIM, Barcelona, Spain (författare)
  • Colzani, EdoardoEuropean Centre for Disease Control and prevention (ECDC), Solna, Sweden (författare)
  • Daneš, JanCharles University in Prague, Prague, Czech Republic (författare)
  • Fitzpatrick, PatriciaNational Screening Service, Dublin, Ireland (författare)
  • Giordano, LiviaCPO-Piedmont - AOU Citta` della Salute e della Scienza, Torino, Italy (författare)
  • Hofvind, SolveigCancer Registry of Norway, Oslo, Norway (författare)
  • Ioannidou-Mouzaka, LydiaUniversity of Athens Medical School, Athens, Greece (författare)
  • Knox, SusanEuropa Donna, Milan, Italy (författare)
  • Nyström, Lennarth,1944-Umeå universitet,Institutionen för epidemiologi och global hälsa(Swepub:umu)leny0002 (författare)
  • Parmelli, ElenaEuropean Commission, Joint Research Centre, Ispra, Italy (författare)
  • Perez, ElsaUniversity Hospital Dr. Josep Trueta, Girona, Spain (författare)
  • Torresin, AlbertoOspedale Niguarda Ca’ Granda, Milan, Italy (författare)
  • Van Engen, RubenDutch Reference Centre for Screening, Nijmegen, Netherlands (författare)
  • Van Landsveld-Verhoeven, CaryDutch Reference Centre for Screening, Nijmegen, Netherlands (författare)
  • Young, KenNational Coordinating Centre for the Physics of Mammography, Guildford, United Kingdom (författare)
  • Azienda Unità Sanitaria Locale—IRCCS di Reggio Emilia, Reggio Emilia, ItalyDepartment of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:British Journal of Cancer: Springer124:9, s. 1503-15120007-09201532-1827

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