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Sökning: WFRF:(Pietschmann Thomas) > (2020-2024) > Impaired immune res...

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

Ricke-Hoch, Melanie (författare)
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
Stelling, Elisabeth (författare)
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
Lasswitz, Lisa (författare)
Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany
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Gunesch, Antonia P. (författare)
Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany; German Center for Infection Research, Hanover-Braunschweig Site, Braunschweig, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany
Kasten, Martina (författare)
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
Zapatero-Belinchón, Francisco J. (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Avdelningen för virologi,Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany
Brogden, Graham (författare)
Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany
Gerold, Gisa, 1979- (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Avdelningen för virologi,Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany; Department of Biochemistry, University of Veterinary Medicine Hannover, Hanover, Germany
Pietschmann, Thomas (författare)
Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany; German Center for Infection Research, Hanover-Braunschweig Site, Braunschweig, Germany
Montiel, Virginie (författare)
Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium
Balligand, Jean-Luc (författare)
Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium
Facciotti, Federica (författare)
Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy
Hirsch, Emilio (författare)
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy
Gausepohl, Thomas (författare)
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
Elbahesh, Husni (författare)
Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine in Hannover (TiHo), Hannover, Germany
Rimmelzwaan, Guus F. (författare)
Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine in Hannover (TiHo), Hannover, Germany
Höfer, Anne (författare)
Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany; Institute for Pathology, Hannover Medical School, Hanover, Germany
Kühnel, Mark P. (författare)
Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany; Institute for Pathology, Hannover Medical School, Hanover, Germany
Jonigk, Danny (författare)
Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany; Institute for Pathology, Hannover Medical School, Hanover, Germany
Eigendorf, Julian (författare)
Institute of Sports Medicine, Hannover Medical School, Hanover, Germany
Tegtbur, Uwe (författare)
Institute of Sports Medicine, Hannover Medical School, Hanover, Germany
Mink, Lena (författare)
Institute of Sports Medicine, Hannover Medical School, Hanover, Germany
Scherr, Michaela (författare)
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany
Illig, Thomas (författare)
Hannover Unified Biobank (HUB), Hannover Medical School, Hanover, Germany
Schambach, Axel (författare)
Institute of Experimental Hematology, Hannover Medical School, Hanover, Germany; Division of Hematology and Oncology, Boston Children’s Hospital, Harvard Medical School, MA, Boston, United States
Pfeffer, Tobias J. (författare)
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
Hilfiker, Andres (författare)
Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany
Haverich, Axel (författare)
Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany
Hilfiker-Kleiner, Denise (författare)
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany; Department of Cardiovascular Complications of Oncologic Therapies, Medical Faculty of the Philipps University Marburg, Marburg, Germany
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 (creator_code:org_t)
2021-08-04
2021
Engelska.
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:8
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://journals.plo...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglan-din-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

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