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  • Ricke-Hoch, MelanieDepartment of Cardiology and Angiology, Hannover Medical School, Hanover, Germany (författare)

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-08-04
  • Public Library of Science (PLoS),2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-186642
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186642URI
  • https://doi.org/10.1371/journal.pone.0255335DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglan-din-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stelling, ElisabethDepartment of Cardiology and Angiology, Hannover Medical School, Hanover, Germany (författare)
  • Lasswitz, LisaInstitute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany (författare)
  • Gunesch, Antonia P.Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany; German Center for Infection Research, Hanover-Braunschweig Site, Braunschweig, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany (författare)
  • Kasten, MartinaDepartment of Cardiology and Angiology, Hannover Medical School, Hanover, Germany (författare)
  • Zapatero-Belinchón, Francisco J.Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Avdelningen för virologi,Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany (författare)
  • Brogden, GrahamInstitute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany (författare)
  • Gerold, Gisa,1979-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Avdelningen för virologi,Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany; Department of Biochemistry, University of Veterinary Medicine Hannover, Hanover, Germany(Swepub:umu)gige0003 (författare)
  • Pietschmann, ThomasInstitute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany; German Center for Infection Research, Hanover-Braunschweig Site, Braunschweig, Germany (författare)
  • Montiel, VirginiePole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium (författare)
  • Balligand, Jean-LucPole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium (författare)
  • Facciotti, FedericaDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy (författare)
  • Hirsch, EmilioDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy (författare)
  • Gausepohl, ThomasDepartment of Cardiology and Angiology, Hannover Medical School, Hanover, Germany (författare)
  • Elbahesh, HusniResearch Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine in Hannover (TiHo), Hannover, Germany (författare)
  • Rimmelzwaan, Guus F.Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine in Hannover (TiHo), Hannover, Germany (författare)
  • Höfer, AnneBiomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany; Institute for Pathology, Hannover Medical School, Hanover, Germany (författare)
  • Kühnel, Mark P.Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany; Institute for Pathology, Hannover Medical School, Hanover, Germany (författare)
  • Jonigk, DannyBiomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany; Institute for Pathology, Hannover Medical School, Hanover, Germany (författare)
  • Eigendorf, JulianInstitute of Sports Medicine, Hannover Medical School, Hanover, Germany (författare)
  • Tegtbur, UweInstitute of Sports Medicine, Hannover Medical School, Hanover, Germany (författare)
  • Mink, LenaInstitute of Sports Medicine, Hannover Medical School, Hanover, Germany (författare)
  • Scherr, MichaelaDepartment of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany (författare)
  • Illig, ThomasHannover Unified Biobank (HUB), Hannover Medical School, Hanover, Germany (författare)
  • Schambach, AxelInstitute of Experimental Hematology, Hannover Medical School, Hanover, Germany; Division of Hematology and Oncology, Boston Children’s Hospital, Harvard Medical School, MA, Boston, United States (författare)
  • Pfeffer, Tobias J.Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany (författare)
  • Hilfiker, AndresDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany (författare)
  • Haverich, AxelDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany (författare)
  • Hilfiker-Kleiner, DeniseDepartment of Cardiology and Angiology, Hannover Medical School, Hanover, Germany; Department of Cardiovascular Complications of Oncologic Therapies, Medical Faculty of the Philipps University Marburg, Marburg, Germany (författare)
  • Department of Cardiology and Angiology, Hannover Medical School, Hanover, GermanyInstitute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library of Science (PLoS)16:81932-6203

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