Elevated Faecal Calprotectin in Patients with a Normal Colonoscopy: Does It Matter in Clinical Practice? A Retrospective Observational Study

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Hovstadius, HenrikUmeå universitet,Avdelningen för medicin (författare)

Elevated Faecal Calprotectin in Patients with a Normal Colonoscopy : Does It Matter in Clinical Practice? A Retrospective Observational Study

Artikel/kapitelEngelska2021

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2021-02-17
S. Karger,2021
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-186650
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186650URI
https://doi.org/10.1159/000513473DOI

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Språk:engelska
Sammanfattning på:engelska

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Introduction: Faecal calprotectin (FC) is commonly used as a diagnostic tool for patients with gastrointestinal (GI) symptoms. However, there is uncertainty in daily clinical practice how to interpret an elevated FC in patients with a normal colonoscopy. We investigated if patients with a normal colonoscopy but with an elevated FC more often were diagnosed with a GI disease in a 3-year follow-up period.Methods: Patients referred for colonoscopy (n = 1,263) to the Umeå University Hospital endoscopy unit between 2007 and 2013 performed a FC test (CALPRO®) on the day before bowel preparation. A medical chart review was performed on all patients who had normal findings on their colonoscopy (n = 585, median age 64 years).Results: Thirty-four percent of the patients (n = 202) with normal colonoscopy had elevated FC (>50 μg/g), and these patients were more frequently diagnosed with upper GI disease during the follow-up period than patients with normal FC levels (9.9 vs. 4.7%; p = 0.015). The upper GI diseases were mainly benign (i.e., gastritis). In a binary logistic regression analysis controlling for age, gender, nonsteroid anti-inflammatory drug use, and proton-pump inhibitor use, there was no difference for a new diagnosis of upper GI disease in the follow-up period (multivariate OR 1.70; 95% CI: 0.77–3.74). There was no difference in a new diagnosis of lower GI disease (6.4 vs. 5.2%; p = 0.545) or cardiovascular disease/death (multivariate OR 1.68; 95% CI: 0.83–3.42) in the follow-up period between patients with elevated versus normal FC levels.Conclusions: In patients with a normal colonoscopy, a simultaneously measured increased FC level was not associated with an increased risk for significant GI disease during a follow-up period of 3 years.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Faecal calprotectin
Colonoscopy
Cardiovascular disease
Colorectal cancer
Diverticular disease
Esophagitis
Gastritis
Inflammatory bowel disease

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lundgren, DavidUmeå universitet,Avdelningen för medicin(Swepub:umu)dadlun96 (författare)
Karling, PontusUmeå universitet,Avdelningen för medicin(Swepub:umu)peakag84 (författare)
Umeå universitetAvdelningen för medicin (creator_code:org_t)

Sammanhörande titlar

Ingår i:Inflammatory Intestinal Diseases: S. Karger6, s. 101-1082296-94032296-9365

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Inflammatory Intestinal Diseases (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Hovstadius, Henr ...; Lundgren, David; Karling, Pontus

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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Av lärosätet: Umeå universitet

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