WFRF:(Xue Kun)
Sökning: WFRF:(Xue Kun) > (2020-2024) > STING inhibitors se...
- Liu, JialeShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
STING inhibitors sensitize platinum chemotherapy in ovarian cancer by inhibiting the CGAS-STING pathway in cancer-associated fibroblasts (CAFs)
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
- Elsevier,2024
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-527897
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-527897URI
- https://doi.org/10.1016/j.canlet.2024.216700DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Chemotherapy resistance in ovarian cancer hampers cure rates, with cancer-associated fibroblasts (CAFs) playing a pivotal role. Despite their known impact on cancer progression and chemotherapy resistance, the specific mechanism by which CAFs regulate the tumor inflammatory environment remains unclear. This study reveals that cisplatin facilitates DNA transfer from ovarian cancer cells to CAFs, activating the CGAS-STING-IFNB1 pathway in CAFs and promoting IFNB1 release. Consequently, this reinforces cancer cell resistance to platinum drugs. High STING expression in the tumor stroma was associated with a poor prognosis, while inhibiting STING expression enhanced ovarian cancer sensitivity. Understanding the relevance of the CGAS-STING pathway in CAFs for platinum resistance suggests targeting STING as a promising combination therapy for ovarian cancer, providing potential avenues for improved treatment outcomes.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Ovarian cancer
- Chemoresistance
- Cancer -associated fibroblasts
- STING inhibitors
- IFNB1
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Liu, ChenmianShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Ma, YanaShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Pan, XiyuShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Chu, RanShandong First Med Univ, Shandong Prov Hosp, Dept Obstet & Gynecol, Jinan 250021, Shandong, Peoples R China. (författare)
- Yao, ShuShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Chen, JunyuShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Liu, ChangShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Chen, ZhongshaoShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Sheng, ChenchenShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Zhang, KaiShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Xue, YingShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Schiöth, HelgiUppsala universitet,Funktionell farmakologi och neurovetenskap(Swepub:uu)helgschi (författare)
- Kong, BeihuaShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Zhang, QingShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Song, KunShandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. (författare)
- Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.Shandong First Med Univ, Shandong Prov Hosp, Dept Obstet & Gynecol, Jinan 250021, Shandong, Peoples R China. (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Cancer Letters: Elsevier5880304-38351872-7980
Internetlänk
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- Ma, Yana
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- Chen, Junyu
- Liu, Chang
- Chen, Zhongshao
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