SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Hankinson Susan)
 

Sökning: WFRF:(Hankinson Susan) > Prolactin and risk ...

  • Hathaway, Cassandra A.Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States (författare)

Prolactin and risk of epithelial ovarian cancer

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • American Association for Cancer Research (AACR),2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-187455
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187455URI
  • https://doi.org/10.1158/1055-9965.EPI-21-0139DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Prolactin is synthesized in the ovaries and may play a role in ovarian cancer etiology. One prior prospective study observed a suggestive positive association between prolactin levels and risk of ovarian cancer.Methods: Weconducted a pooled case-control study of 703 cases and 864 matched controls nested within five prospective cohorts. We used unconditional logistic regression to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between prolactin and ovarian cancer risk. We examined heterogeneity by menopausal status at blood collection, body mass index (BMI), age, and histotype.Results: Among women with known menopausal status, we observed a positive trend in the association between prolactin and ovarian cancer risk (Ptrend = 0.045; OR, quartile 4 vs. 1 = 1.34; 95% CI = 0.97–1.85), but no significant association was observed for premenopausal or postmenopausal women individually (corresponding OR = 1.38; 95% CI = 0.74–2.58; Ptrend = 0.32 and OR = 1.41; 95% CI = 0.93–2.13; Ptrend = 0.08, respectively; Pheterogeneity = 0.91). In stratified analyses, we observed a positive association between prolactin and risk for women with BMI ≥ 25 kg/m2, but not BMI < 25 kg/m2 (corresponding OR = 2.68; 95% CI = 1.56–4.59; Ptrend < 0.01 and OR = 0.90; 95% CI = 0.58–1.40; Ptrend = 0.98, respectively; Pheterogeneity < 0.01). Associations did not vary by age, postmenopausal hormone therapy use, histotype, or time between blood draw and diagnosis.Conclusions: We found a trend between higher prolactin levels and increased ovarian cancer risk, especially among women with a BMI ≥ 25 kg/m2.Impact: This work supports a previous study linking higher prolactin with ovarian carcinogenesis in a high adiposity setting. Future work is needed to understand the mechanism underlying this association.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rice, Megan S.Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States (författare)
  • Townsend, Mary K.Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States (författare)
  • Hankinson, Susan E.Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, MA, Amherst, United States (författare)
  • Arslan, Alan A.Department of Obstetrics and Gynecology, New York University Langone Health, NY, New York, United States; Department of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States (författare)
  • Buring, Julie E.Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (författare)
  • Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001 (författare)
  • Idahl, Annika,1965-Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002 (författare)
  • Kubzansky, Laura D.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (författare)
  • Lee, I-MinDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (författare)
  • Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001 (författare)
  • Sluss, Patrick M.Department of Pathology, Massachusetts General Hospital, MA, Boston, United States (författare)
  • Zeleniuch-Jacquotte, AnneDepartment of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States (författare)
  • Tworoger, Shelley S.Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (författare)
  • Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United StatesClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research (AACR)30:9, s. 1652-16591055-99651538-7755

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy