Sökning: WFRF:(Hankinson Susan E) >
Prolactin and risk ...
Prolactin and risk of epithelial ovarian cancer
-
- Hathaway, Cassandra A. (författare)
- Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States
-
- Rice, Megan S. (författare)
- Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States
-
- Townsend, Mary K. (författare)
- Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States
-
visa fler...
-
- Hankinson, Susan E. (författare)
- Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, MA, Amherst, United States
-
- Arslan, Alan A. (författare)
- Department of Obstetrics and Gynecology, New York University Langone Health, NY, New York, United States; Department of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States
-
- Buring, Julie E. (författare)
- Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
-
- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning
-
- Idahl, Annika, 1965- (författare)
- Umeå universitet,Obstetrik och gynekologi
-
- Kubzansky, Laura D. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
-
- Lee, I-Min (författare)
- Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
-
- Lundin, Eva (författare)
- Umeå universitet,Patologi
-
- Sluss, Patrick M. (författare)
- Department of Pathology, Massachusetts General Hospital, MA, Boston, United States
-
- Zeleniuch-Jacquotte, Anne (författare)
- Department of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States
-
- Tworoger, Shelley S. (författare)
- Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
-
visa färre...
-
(creator_code:org_t)
- American Association for Cancer Research (AACR), 2021
- 2021
- Engelska.
-
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 30:9, s. 1652-1659
- Relaterad länk:
-
https://www.ncbi.nlm...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Prolactin is synthesized in the ovaries and may play a role in ovarian cancer etiology. One prior prospective study observed a suggestive positive association between prolactin levels and risk of ovarian cancer.Methods: Weconducted a pooled case-control study of 703 cases and 864 matched controls nested within five prospective cohorts. We used unconditional logistic regression to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between prolactin and ovarian cancer risk. We examined heterogeneity by menopausal status at blood collection, body mass index (BMI), age, and histotype.Results: Among women with known menopausal status, we observed a positive trend in the association between prolactin and ovarian cancer risk (Ptrend = 0.045; OR, quartile 4 vs. 1 = 1.34; 95% CI = 0.97–1.85), but no significant association was observed for premenopausal or postmenopausal women individually (corresponding OR = 1.38; 95% CI = 0.74–2.58; Ptrend = 0.32 and OR = 1.41; 95% CI = 0.93–2.13; Ptrend = 0.08, respectively; Pheterogeneity = 0.91). In stratified analyses, we observed a positive association between prolactin and risk for women with BMI ≥ 25 kg/m2, but not BMI < 25 kg/m2 (corresponding OR = 2.68; 95% CI = 1.56–4.59; Ptrend < 0.01 and OR = 0.90; 95% CI = 0.58–1.40; Ptrend = 0.98, respectively; Pheterogeneity < 0.01). Associations did not vary by age, postmenopausal hormone therapy use, histotype, or time between blood draw and diagnosis.Conclusions: We found a trend between higher prolactin levels and increased ovarian cancer risk, especially among women with a BMI ≥ 25 kg/m2.Impact: This work supports a previous study linking higher prolactin with ovarian carcinogenesis in a high adiposity setting. Future work is needed to understand the mechanism underlying this association.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hathaway, Cassan ...
-
Rice, Megan S.
-
Townsend, Mary K ...
-
Hankinson, Susan ...
-
Arslan, Alan A.
-
Buring, Julie E.
-
visa fler...
-
Hallmans, Göran, ...
-
Idahl, Annika, 1 ...
-
Kubzansky, Laura ...
-
Lee, I-Min
-
Lundin, Eva
-
Sluss, Patrick M ...
-
Zeleniuch-Jacquo ...
-
Tworoger, Shelle ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
- Artiklar i publikationen
-
Cancer Epidemiol ...
- Av lärosätet
-
Umeå universitet