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The Cerebrospinal F...
The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features
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- Griffiths, William J. (author)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
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- Abdel-Khalik, Jonas (author)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
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- Moore, Sarah F. (author)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
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- Wijeyekoon, Ruwani S. (author)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
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- Crick, Peter J. (author)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
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- Yutuc, Eylan (author)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
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- Farrell, Krista (author)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
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- Breen, David P. (author)
- Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, United Kingdom; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
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- Williams-Gray, Caroline H. (author)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
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- Theofilopoulos, Spyridon (author)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
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- Arenas, Ernest (author)
- Karolinska Institutet
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- Trupp, Miles (author)
- Umeå universitet,Neurovetenskaper
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- Barker, Roger A. (author)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
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- Wang, Yuqin (author)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
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(creator_code:org_t)
- 2021-08-30
- 2021
- English.
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In: Frontiers in Aging Neuroscience. - : Frontiers Media S.A.. - 1663-4365. ; 13
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Abstract
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- Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydroxycholesterol and a second oxysterol 7α,x,y-trihydroxycholest-4-en-3-one (7α,x,y-triHCO), whose exact structure is unknown, were found to be significantly elevated in PD CSF. The likely location of the additional hydroxy groups on the second oxysterol are on the sterol side-chain. We found that CSF 7α-hydroxycholesterol levels correlated positively with depression in PD patients, while two presumptively identified cholestenoic acids correlated negatively with depression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- bile acid biosynthesis
- dihydroxycholesterol
- mass spectrometry
- oxysterol
- sterol
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Griffiths, Willi ...
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Abdel-Khalik, Jo ...
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Moore, Sarah F.
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Wijeyekoon, Ruwa ...
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Crick, Peter J.
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Yutuc, Eylan
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show more...
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Farrell, Krista
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Breen, David P.
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Williams-Gray, C ...
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Theofilopoulos, ...
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Arenas, Ernest
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Trupp, Miles
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Barker, Roger A.
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Wang, Yuqin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Frontiers in Agi ...
- By the university
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Umeå University
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Karolinska Institutet