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  • Griffiths, William J.Swansea University Medical School, ILS1 Building, Swansea, United Kingdom (författare)

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-08-30
  • Frontiers Media S.A.2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-187745
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187745URI
  • https://doi.org/10.3389/fnagi.2021.685594DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148075552URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydroxycholesterol and a second oxysterol 7α,x,y-trihydroxycholest-4-en-3-one (7α,x,y-triHCO), whose exact structure is unknown, were found to be significantly elevated in PD CSF. The likely location of the additional hydroxy groups on the second oxysterol are on the sterol side-chain. We found that CSF 7α-hydroxycholesterol levels correlated positively with depression in PD patients, while two presumptively identified cholestenoic acids correlated negatively with depression.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Abdel-Khalik, JonasSwansea University Medical School, ILS1 Building, Swansea, United Kingdom (författare)
  • Moore, Sarah F.Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (författare)
  • Wijeyekoon, Ruwani S.Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (författare)
  • Crick, Peter J.Swansea University Medical School, ILS1 Building, Swansea, United Kingdom (författare)
  • Yutuc, EylanSwansea University Medical School, ILS1 Building, Swansea, United Kingdom (författare)
  • Farrell, KristaDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (författare)
  • Breen, David P.Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, United Kingdom; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Williams-Gray, Caroline H.Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (författare)
  • Theofilopoulos, SpyridonSwansea University Medical School, ILS1 Building, Swansea, United Kingdom (författare)
  • Arenas, ErnestKarolinska Institutet (författare)
  • Trupp, MilesUmeå universitet,Neurovetenskaper(Swepub:umu)mitr0006 (författare)
  • Barker, Roger A.Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom (författare)
  • Wang, YuqinSwansea University Medical School, ILS1 Building, Swansea, United Kingdom (författare)
  • Swansea University Medical School, ILS1 Building, Swansea, United KingdomDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Aging Neuroscience: Frontiers Media S.A.131663-4365

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