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Prevalence of Subcl...
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,The County of Västra Götaland,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Persson, Margaretha (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Adiels, Martin, 1976 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, Department of Molecular and Clinical Medicine,Institute of Medicine, School of Public Health and Community Medicine
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show more...
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- Björnson, Elias, 1988 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Bonander, Carl (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
-
- Ahlström, Håkan, 1953- (author)
- Uppsala University,Uppsala universitet,Radiologi
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- Alfredsson, Joakim, 1962- (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping Univ, Dept Cardiol Hlth Med & Caring Sci, Linköping, Sweden.
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- Angerås, Oskar, 1976 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,The County of Västra Götaland,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Berglund, Göran (author)
- Lund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups
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- Blomberg, Anders, 1961- (author)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med Med, Umeå, Sweden.;Umeå Univ, Heart Ctr, Umeå, Sweden.
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- Brandberg, John, 1966 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,The County of Västra Götaland,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Börjesson, Mats, 1965 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Centrum för hälsa och prestationsutveckling,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Health and Performance,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Cederlund, Kerstin (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.
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- de Faire, Ulf (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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- Duvernoy, Olov (author)
- Uppsala University,Uppsala universitet,Radiologi,Olov.Duvernoy@radiol.uu.se
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- Ekblom, Örjan (author)
- Swedish School of Sport and Health Sciences
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Engvall, Jan (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US,Linköping Univ, Dept Cardiol Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, Dept Clin Physiol, Linköping, Sweden.;Linköping Univ, CMIV, Ctr Med Image Sci & Visualizat, Linköping, Sweden.
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- Fagman, Erika (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,The County of Västra Götaland,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Eriksson, Mats (author)
- Karolinska Univ Hosp Huddinge, Dept Endocrinol Metab & Diabet, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Clin Res Ctr, Stockholm, Sweden.,Karolinska University Hospital
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- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Fagerberg, Björn, 1943 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Flinck, Agneta, 1953 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Gonçalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Hagström, Emil (author)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Hjelmgren, Ola (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,The County of Västra Götaland,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Lind, Lars (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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- Lindberg, Eva (author)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning
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- Lindqvist, Per (author)
- Umeå University,Umeå universitet,Klinisk fysiologi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
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- Ljungberg, Johan (author)
- Umeå University,Umeå universitet,Kardiologi,Umeå Univ, Dept Publ Hlth & Clin Med Med, Umeå, Sweden.;Umeå Univ, Heart Ctr, Umeå, Sweden.
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- Magnusson, Martin (author)
- Lund University,Lunds universitet,Karolinska Institutet,Lund Univ, Dept Clin Sci, Malmö, Sweden.;Skane Univ Hosp, Dept Cardiol, Malmö, Sweden.;Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden.;North West Univ, Hypertens Africa Res Team HART, Potchefstroom, South Africa.,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital,North-West University
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- Mannila, Maria (author)
- Karolinska Univ Hosp, Dept Cardiol & Clin Genet, Heart & Vasc Theme, Stockholm, Sweden.,Karolinska University Hospital
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- Markstad, Hanna (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Epidemiology,Lund University Research Groups,Cardiovascular Research - Translational Studies,Skåne University Hospital
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- Mohammad, Moman A (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Nyström, Fredrik H (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Cityhälsan Centrum,Linköping Univ, Dept Cardiol Hlth Med & Caring Sci, Linköping, Sweden.
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- Ostenfeld, Ellen (author)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Persson, Anders (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping,Linköping Univ, Dept Cardiol Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, Dept Radiol, Linköping, Sweden.;Linköping Univ, CMIV, Ctr Med Image Sci & Visualizat, Linköping, Sweden.
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Sandström, Anette (author)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med Med, Umeå, Sweden.;Umeå Univ, Heart Ctr, Umeå, Sweden.
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- Själander, Anders (author)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med Med, Umeå, Sweden.;Umeå Univ, Heart Ctr, Umeå, Sweden.
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- Sköld, Magnus C. (author)
- Karolinska Institute,Karolinska University Hospital
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.,University of New South Wales
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- Swahn, Eva (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping Univ, Dept Cardiol Hlth Med & Caring Sci, Linköping, Sweden.
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- Söderberg, Stefan (author)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med Med, Umeå, Sweden.;Umeå Univ, Heart Ctr, Umeå, Sweden.
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- Torén, Kjell (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Östgren, Carl Johan (author)
- Linköping University,Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Vårdcentralen Ekholmen,Linköping Univ, Dept Cardiol Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, CMIV, Ctr Med Image Sci & Visualizat, Linköping, Sweden.
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- Jernberg, Tomas (author)
- Karolinska Institute,Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Stockholm, Sweden.
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(creator_code:org_t)
- Philadelphia : American Heart Association, 2021
- 2021
- English.
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In: Circulation. - Philadelphia : American Heart Association. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
- Related links:
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Abstract
Subject headings
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- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- coronary angiography
- coronary artery disease
- epidemiology
- plaque
- atherosclerotic
- primary prevention
- tomography
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bergström, Göran ...
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Persson, Margare ...
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Adiels, Martin, ...
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Björnson, Elias, ...
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Bonander, Carl
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Ahlström, Håkan, ...
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Alfredsson, Joak ...
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Angerås, Oskar, ...
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Berglund, Göran
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Blomberg, Anders ...
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Brandberg, John, ...
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Börjesson, Mats, ...
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Cederlund, Kerst ...
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de Faire, Ulf
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Duvernoy, Olov
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Ekblom, Örjan
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Engström, Gunnar
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Engvall, Jan
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Fagman, Erika
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Eriksson, Mats
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Erlinge, David
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Fagerberg, Björn ...
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Flinck, Agneta, ...
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Gonçalves, Isabe ...
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Hagström, Emil
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Hjelmgren, Ola
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Lind, Lars
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Lindberg, Eva
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Lindqvist, Per
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Ljungberg, Johan
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Magnusson, Marti ...
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Mannila, Maria
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Markstad, Hanna
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Mohammad, Moman ...
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Nyström, Fredrik ...
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Ostenfeld, Ellen
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Persson, Anders
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Rosengren, Annik ...
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Sandström, Anett ...
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Själander, Ander ...
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Sköld, Magnus C.
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Sundström, Johan ...
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Swahn, Eva
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Söderberg, Stefa ...
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Torén, Kjell
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Östgren, Carl Jo ...
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Jernberg, Tomas
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- MEDICAL AND HEALTH SCIENCES
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Circulation
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Umeå University
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Linköping University
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Karolinska Institutet
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