(WFRF:(Alanentalo Tomas)) conttype:(refereed)
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- Hahn, MaxUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden. (author)
3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-09-10
- Springer Nature,2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-187770
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187770URI
- https://doi.org/10.1038/s42003-021-02589-xDOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-456501URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The possibility to quantitatively study specific molecular/cellular features of complete human organs with preserved spatial 3D context would have widespread implications for pre-clinical and clinical medicine. Whereas optical 3D imaging approaches have experienced a formidable revolution, they have remained limited due to current incapacities in obtaining specific labelling within large tissue volumes. We present a simple approach enabling reconstruction of antibody labeled cells within entire human organs with preserved organ context. We demonstrate the utility of the approach by providing volumetric data and 3D distribution of hundreds of thousands of islets of Langerhans within the human pancreas. By assessments of pancreata from non-diabetic and type 2 diabetic individuals, we display previously unrecognized features of the human islet mass distribution and pathology. As such, this method may contribute not only in unraveling new information of the pancreatic anatomy/pathophysiology, but it may be translated to essentially any antibody marker or organ system.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Nord, ChristofferUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.(Swepub:umu)chsv0004 (author)
- Eriksson, MariaUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.(Swepub:umu)maer0057 (author)
- Morini, FedericoUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.(Swepub:umu)femo0004 (author)
- Alanentalo, TomasUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.(Swepub:umu)tosalo98 (author)
- Korsgren, OlleUppsala universitet,Klinisk immunologi(Swepub:uu)ollekors (author)
- Ahlgren, UlfUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.(Swepub:umu)ulah0001 (author)
- Umeå universitetUmeå centrum för molekylär medicin (UCMM) (creator_code:org_t)
Related titles
- In:Communications Biology: Springer Nature4:12399-3642
Internet link
- https://doi.org/10.1038/s42003-021-02589-xFulltext
- https://umu.diva-portal.org/smash/get/diva2:1596450/FULLTEXT01.pdffulltext:print
- https://www.nature.com/articles/s42003-021-02589-x.pdf
- https://uu.diva-portal.org/smash/get/diva2:1605607/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187770
- https://doi.org/10.1038/s42003-021-02589-x
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-456501
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