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Investigation of multiple populations highlight VEGFA polymorphisms to modulate anterior cruciate ligament injury

Feldmann, Daneil C. (författare)
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa
Rahim, Masouda (författare)
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa
Suijkerbuijk, Mathijs A. M. (författare)
Department of Orthopaedic Surgery, Erasmus MC, University Medical Center, Rotterdam, Netherlands,Univ Med Ctr, Dept Orthopaed Surg, Erasmus MC, Rotterdam, Netherlands
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Laguette, Mary-Jessica N. (författare)
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; UCT Research Centre for Health through Physical Activity, Lifestyle and Sport, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;UCT Res Ctr Hlth Phys Act Lifestyle & Sport, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
Cieszczyk, Paweł (författare)
Faculty of Physical Education, Gdańsk University of Physical Education and Sport, Gdańsk, Poland,Gdansk Univ Phys Educ & Sport, Fac Phys Educ, Gdansk, Poland
Ficek, Krzysztof (författare)
Faculty of Physiotherapy, Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland,Jerzy Kukuczka Acad Phys Educ Katowice, Fac Physiotherapy, Katowice, Poland
Huminska-Lisowska, Kinga (författare)
Faculty of Physical Education, Gdańsk University of Physical Education and Sport, Gdańsk, Poland,Gdansk Univ Phys Educ & Sport, Fac Phys Educ, Gdansk, Poland
Häger, Charlotte K., Professor, 1962- (författare)
Umeå universitet,Institutionen för samhällsmedicin och rehabilitering,Umeå Univ, Dept Community Med & Rehabil, Umeå, Sweden
Stattin, Evalena (författare)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
Nilsson, Kjell G. (författare)
Umeå universitet,Ortopedi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden
Alvarez-Rumero, Javier (författare)
Institute for Health and Sport (iHeS), Victoria University, VIC, Melbourne, Australia,Victoria Univ, Inst Hlth & Sport iHeS, Melbourne, Vic, Australia
Eynon, Nir (författare)
Institute for Health and Sport (iHeS), Victoria University, VIC, Melbourne, Australia,Victoria Univ, Inst Hlth & Sport iHeS, Melbourne, Vic, Australia
Feller, Julian (författare)
OrthoSport Victoria, Epworth Healthcare, VIC, Melbourne, Australia
Tirosh, Oren (författare)
School of Health Sciences, Swinburne University of Technology, VIC, Melbourne, Australia,Swinburne Univ Technol, Sch Hlth Sci, Melbourne, Vic, Australia
Posthumus, Michael (författare)
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
Chimusa, Emile R. (författare)
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Pathology, Division of Human Genetics, University of Cape Town, Cape Town, South Africa,Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Cape Town, South Africa.;Univ Cape Town, Dept Pathol, Div Human Genet, Cape Town, South Africa
Collins, Malcolm (författare)
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; UCT Research Centre for Health through Physical Activity, Lifestyle and Sport, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;UCT Res Ctr Hlth Phys Act Lifestyle & Sport, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
September, Alison V. (författare)
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; UCT Research Centre for Health through Physical Activity, Lifestyle and Sport, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;UCT Res Ctr Hlth Phys Act Lifestyle & Sport, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
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 (creator_code:org_t)
2021-10-18
2022
Engelska.
Ingår i: Journal of Orthopaedic Research. - : John Wiley & Sons. - 0736-0266 .- 1554-527X. ; 40:7, s. 1604-1612
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Polymorphisms in VEGFA and KDR encoding proteins have been associated with anterior cruciate ligament (ACL) injury risk. We leveraged a collective sample from Sweden, Poland, and Australia to investigate the association of functional polymorphisms in VEGFA and KDR with susceptibility to ACL injury risk. Using a case–control genetic association approach, polymorphisms in VEGFA and KDR were genotyped and haplotypes inferred from 765 controls, and 912 cases clinically diagnosed with ACL rupture. For VEGFA, there was a significant overrepresentation of the rs2010963 CC genotype (p = 0.0001, false discovery rate [FDR]: p = 0.001, odds ratio [OR]: 2.16, 95% confidence interval [CI]: 1.47–3.19) in the combined ACL group (18%) compared to the combined control group (11%). The VEGFA (rs699947 C/A, rs1570360 G/A, rs2010963 G/C) A-A-G haplotype was significantly (p = 0.010, OR: 0.85, 95% CI: 0.69–1.05) underrepresented in the combined ACL group (23%) compared to the combined control group (28%). In addition, the A-G-G construct was significantly (p = 0.036, OR: 0.81, 95% CI: 0.64–1.02) underrepresented in the combined ACL group (12%) compared to the combined CON group (16%). Our findings support the association of the VEGFA rs2010963 CC genotype with increased risk and (ii) the VEGFA A-A-G haplotype with a reduced risk, and are in alignment with the a priori hypothesis. Collectively identifying a genetic interval within VEGFA to be implicated in ACL risk modulation and highlight further the importance of vascular regulation in ligament biology.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Physiotherapy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)

Nyckelord

ACL
angiogenesis
genetic association studies
ligament healing

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