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  • Guo, JinanJinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.,Jinan University (författare)

Non-invasive Urine Test for Molecular Classification of Clinical Significance in Newly Diagnosed Prostate Cancer Patients

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-09-14
  • Frontiers Media S.A.2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-189150
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189150URI
  • https://doi.org/10.3389/fmed.2021.721554DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-47867URI
  • https://lup.lub.lu.se/record/606c52dd-b9f2-4bd4-9fd5-85548067b5c3URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: To avoid over-treatment of low-risk prostate cancer patients, it is important to identify clinically significant and insignificant cancer for treatment decision-making. However, no accurate test is currently available.Methods: To address this unmet medical need, we developed a novel gene classifier to distinguish clinically significant and insignificant cancer, which were classified based on the National Comprehensive Cancer Network risk stratification guidelines. A non-invasive urine test was developed using quantitative mRNA expression data of 24 genes in the classifier with an algorithm to stratify the clinical significance of the cancer. Two independent, multicenter, retrospective and prospective studies were conducted to assess the diagnostic performance of the 24-Gene Classifier and the current clinicopathological measures by univariate and multivariate logistic regression and discriminant analysis. In addition, assessments were performed in various Gleason grades/ISUP Grade Groups.Results: The results showed high diagnostic accuracy of the 24-Gene Classifier with an AUC of 0.917 (95% CI 0.892-0.942) in the retrospective cohort (n = 520), AUC of 0.959 (95% CI 0.935-0.983) in the prospective cohort (n = 207), and AUC of 0.930 (95% 0.912-CI 0.947) in the combination cohort (n = 727). Univariate and multivariate analysis showed that the 24-Gene Classifier was more accurate than cancer stage, Gleason score, and PSA, especially in the low/intermediate-grade/ISUP Grade Group 1-3 cancer subgroups.Conclusions: The 24-Gene Classifier urine test is an accurate and non-invasive liquid biopsy method for identifying clinically significant prostate cancer in newly diagnosed cancer patients. It has the potential to improve prostate cancer treatment decisions and active surveillance.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhang, XuhuiInst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences (författare)
  • Xia, TaolinFoshan First Peoples Hosp, Dept Urol, Foshan, Peoples R China.,Foshan First People’s Hospital (författare)
  • Johnson, HeatherOlympia Diagnost Inc, Sunnyvale, CA USA.,Olympia Diagnostics Inc. (författare)
  • Feng, XiaoyanInst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences (författare)
  • Simoulis, AthanasiosSkane Univ Hosp, Dept Clin Pathol & Cytol, Malmo, Sweden.,Skåne University Hospital(Swepub:lu)at5550si (författare)
  • Wu, Alan H. B.San Francisco Gen Hosp, Clin Labs, San Francisco, CA 94110 USA.,San Francisco General Hospital (författare)
  • Li, FeiSouthern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou, Peoples R China.,Southern Medical University (författare)
  • Tan, WanlongSouthern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou, Peoples R China.,Southern Medical University (författare)
  • Johnson, AllanKinet Real, Santa Clara, CA USA.,Kinetic Reality (författare)
  • Dizeyi, NishtmanLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Urological research, Malmö,Lund University Research Groups(Swepub:lu)kir-dni (författare)
  • Abrahamsson, Per AndersLund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups(Swepub:lu)uro-paa (författare)
  • Kenner, LukasMed Univ Vienna, Dept Expt Pathol, Vienna, Austria.;Univ Vet Med, Unit Lab Anim Pathol, Vienna, Austria.,Medical University of Vienna (författare)
  • Xiao, KefengJinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.,Jinan University (författare)
  • Zhang, HeqiuInst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences (författare)
  • Chen, LingwuSun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.,First Affiliated Hospital of Sun Yat-sen University (författare)
  • Zou, ChangJinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.;Southwest Med Univ, Sch Pharm, Educ Minist, Key Lab Med Electrophysiol, Luzhou, Peoples R China.,Jinan University (författare)
  • Persson, Jenny L.,ProfessorUmeå University,Malmö University,Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö University, Malmö, Sweden; Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Umea Univ, Dept Mol Biol, Umea, Sweden.; Lund Univ, Dept Translat Med, Div Expt Canc Res, Malmo, Sweden.(Swepub:lu)medk-jpe (författare)
  • Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.Jinan University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Medicine: Frontiers Media S.A.82296-858X

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