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Sökning: WFRF:(Bueno De Mesquita Bas H.) > (2020-2023) > Prediagnostic blood...

  • Baker, Jacqueline RoshelliDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States (författare)

Prediagnostic blood selenium status and mortality among patients with colorectal cancer in western european populations

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-10-22
  • MDPI,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-189563
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189563URI
  • https://doi.org/10.3390/biomedicines9111521DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multi-variable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Median follow-up time was 113 months. Participants with Se concentrations in the highest quintile (≥100 µg/L) had a multivariable-adjusted hazard ratio (HR) of 0.73 (95% CI: 0.52–1.02; Ptrend = 0.06) for CRC-specific mortality and 0.77 (95% CI: 0.57–1.03; Ptrend = 0.04) for overall mortality, compared with the lowest quintile (≤67.5 µg/L). Similarly, participants with SELENOP concentrations in the highest (≥5.07 mg/L) compared with the lowest quintile (≤3.53 mg/L) had HRs of 0.89 (95% CI: 0.64–1.24; Ptrend = 0.39) for CRC-specific mortality and 0.83 (95% CI: 0.62–1.11; Ptrend = 0.17) for overall mortal-ity. Higher prediagnostic exposure to Se within an optimal concentration (100–150 µg/L) might be associated with improved survival among CRC patients, although our results were not statistically significant and additional studies are needed to confirm this potential association. Our findings may stimulate further research on selenium’s role in survival among CRC patients especially among those residing in geographic regions with suboptimal Se availability.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Umesh, SushmaDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States (författare)
  • Jenab, MazdaInternational Agency for Research on Cancer, Lyon, France (författare)
  • Schomburg, LutzInstitut für Experimentelle Endokrinologie, Charité Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Tjønneland, AnneDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark (författare)
  • Olsen, AnjaDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark (författare)
  • Boutron-Ruault, Marie-ChristineCESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France (författare)
  • Rothwell, Joseph A.CESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France (författare)
  • Severi, GianlucaCESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications (DISIA), University of Florence, Florence, Italy (författare)
  • Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Johnson, TheronDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany (författare)
  • Masala, GiovannaCancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy (författare)
  • Agnoli, ClaudiaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy (författare)
  • Simeon, VittorioDipartimento di Salute Mentale e Fisica e Medicina Preventiva, Università degli Studi della Campania ‘Luigi Vanvitelli’, Naples, Italy (författare)
  • Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy (författare)
  • Bueno-De-mesquita, H. BasCenter for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands (författare)
  • Gram, Inger TorhildDepartment of Community Medicine, The Arctic University of Norway, Tromsø, Norway (författare)
  • Skeie, GuriDepartment of Community Medicine, The Arctic University of Norway, Tromsø, Norway (författare)
  • Bonet, CatalinaUnitat de Nutrició i Càncer, Malaga, Spain (författare)
  • Rodriguez-Barranco, MiguelEscuela Andaluza de Salud Pública (EASP), Instituto de Investigación Biosanitaria ibs. Granada, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (författare)
  • Houerta, José MaríaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain (författare)
  • Gylling, Björn,1978-Umeå universitet,Patologi(Swepub:umu)bjgy0001 (författare)
  • Van Guelpen, BethanyUmeå universitet,Onkologi(Swepub:umu)beyvan99 (författare)
  • Perez-Cornago, AuroraCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Aglago, ElomInternational Agency for Research on Cancer, Lyon, France (författare)
  • Freisling, HeinzInternational Agency for Research on Cancer, Lyon, France (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, Lyon, France (författare)
  • Cross, Amanda J.School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Heath, Alicia K.School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Hughes, David J.Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland (författare)
  • Fedirko, VeronikaDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, TX, Houston, United States (författare)
  • Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United StatesInternational Agency for Research on Cancer, Lyon, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biomedicines: MDPI9:112227-9059

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