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  • Vidal-Pineiro, DidacCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)

Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • eLife Sciences Publications,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-190112
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190112URI
  • https://doi.org/10.7554/eLife.69995DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Brain age is a widely used index for quantifying individuals’ brain health as deviation from a normative brain aging trajectory. Higher-than-expected brain age is thought partially to reflect above-average rate of brain aging. Here, we explicitly tested this assumption in two indepen-dent large test datasets (UK Biobank [main] and Lifebrain [replication]; longitudinal observations ≈ 2750 and 4200) by assessing the relationship between cross-sectional and longitudinal estimates of brain age. Brain age models were estimated in two different training datasets (n ≈ 38,000 [main] and 1800 individuals [replication]) based on brain structural features. The results showed no association between cross-sectional brain age and the rate of brain change measured longitudinally. Rather, brain age in adulthood was associated with the congenital factors of birth weight and polygenic scores of brain age, assumed to reflect a constant, lifelong influence on brain structure from early life. The results call for nuanced interpretations of cross-sectional indices of the aging brain and question their validity as markers of ongoing within-person changes of the aging brain. Longitudinal imaging data should be preferred whenever the goal is to understand individual change trajectories of brain and cognition in aging.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wang, YunpengCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Krogsrud, Stine K.Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Amlien, Inge K.Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Baaré, William FCDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark (författare)
  • Bartres-Faz, DavidDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain (författare)
  • Bertram, LarsCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lubeck, Germany (författare)
  • Brandmaier, Andreas M.Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (författare)
  • Drevon, Christian A.Department of Nutrition, Inst Basic Med Sciences, Faculty of Medicine, University of Oslo & Vitas Ltd, Oslo, Norway (författare)
  • Düzel, SandraCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (författare)
  • Ebmeier, KlausDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom (författare)
  • Henson, Richard N.MRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom (författare)
  • Junqué, CarmeDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain (författare)
  • Kievit, Rogier AndrewMRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands (författare)
  • Kühn, SimoneLise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (författare)
  • Leonardsen, EstenCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Lindenberger, UlmanMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (författare)
  • Madsen, Kathrine S.Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark (författare)
  • Magnussen, FredrikCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Mowinckel, Athanasia MonikaCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Nyberg, Lars,1966-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi,Diagnostisk radiologi(Swepub:umu)lany0001 (författare)
  • Roe, James M.Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Segura, BarbaraDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain (författare)
  • Smith, Stephen M.Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (författare)
  • Sørensen, ØysteinCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Suri, SanaWellcome Centre for Integrative Neuroimaging (WIN FMRIB), University of Oxford, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, United Kingdom (författare)
  • Westerhausen, ReneSection for Cognitive Neuroscience and Neuropsychology, Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Zalesky, AndrewDepartment of Biomedical Engineering, Faculty of Engineering and IT, The University of Melbourne, Melbourne, Australia (författare)
  • Zsoldos, EnikőWellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, United Kingdom (författare)
  • Walhovd, Kristine BeateCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway (författare)
  • Fjell, AndersCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway (författare)
  • Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, NorwayDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:eLIFE: eLife Sciences Publications102050-084X

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