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Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination

Cagigi, Alberto (författare)
Karolinska Institutet
Yu, Meng (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Österberg, Björn (författare)
Karolinska Institutet
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Svensson, Julia (författare)
Karolinska Institutet
Falck-Jones, Sara (författare)
Karolinska Institutet
Vangeti, Sindhu (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Åhlberg, Eric (författare)
Karolinska Institutet
Azizmohammadi, Lida (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Warnqvist, Anna (författare)
Karolinska Institutet
Falck-Jones, Ryan (författare)
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Gubisch, Pia C. (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Ödemis, Mert (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Ghafoor, Farangies (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Eisele, Mona (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Lenart, Klara (författare)
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Bell, Max (författare)
Karolinska Institutet
Johansson, Niclas (författare)
Division of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital Solna, Stockholm, Sweden
Albert, Jan (författare)
Karolinska Institutet
Sälde, Jörgen (författare)
Närakut SLSO, Karolinska University Hospital Solna, Stockholm, Sweden
Pettie, Deleah D. (författare)
Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
Murphy, Michael P. (författare)
Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
Carter, Lauren (författare)
Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
King, Neil P. (författare)
Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
Ols, Sebastian (författare)
Karolinska Institutet
Normark, Johan (författare)
Umeå universitet,Immunologi/immunkemi
Ahlm, Clas, 1956- (författare)
Umeå universitet,Immunologi/immunkemi
Forsell, Mattias N. (författare)
Umeå universitet,Immunologi/immunkemi
Färnert, Anna (författare)
Karolinska Institutet
Loré, Karin (författare)
Karolinska Institutet
Smed-Sörensen, Anna (författare)
Karolinska Institutet
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 (creator_code:org_t)
2021-11-22
2021
Engelska.
Ingår i: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 6:22
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
http://insight.jci.o...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Understanding the presence and durability of antibodies against SARS-CoV-2 in the airways is required to provide insights into the ability of individuals to neutralize the virus locally and prevent viral spread. Here, we longitudinally assessed both systemic and airway immune responses upon SARS-CoV-2 infection in a clinically well-characterized cohort of 147 infected individuals representing the full spectrum of COVID-19 severity, from asymptomatic infection to fatal disease. In addition, we evaluated how SARS-CoV-2 vaccination influenced the antibody responses in a subset of these individuals during convalescence as compared with naive individuals. Not only systemic but also airway antibody responses correlated with the degree of COVID-19 disease severity. However, although systemic IgG levels were durable for up to 8 months, airway IgG and IgA declined significantly within 3 months. After vaccination, there was an increase in both systemic and airway antibodies, in particular IgG, often exceeding the levels found during acute disease. In contrast, naive individuals showed low airway antibodies after vaccination. In the former COVID-19 patients, airway antibody levels were significantly elevated after the boost vaccination, highlighting the importance of prime and boost vaccinations for previously infected individuals to obtain optimal mucosal protection.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

immunologi
Immunology

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