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Airway antibodies e...
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Cagigi, AlbertoKarolinska Institutet
(author)
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-11-22
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American Society for Clinical Investigation,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-190150
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190150URI
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https://doi.org/10.1172/jci.insight.151463DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148173152URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Understanding the presence and durability of antibodies against SARS-CoV-2 in the airways is required to provide insights into the ability of individuals to neutralize the virus locally and prevent viral spread. Here, we longitudinally assessed both systemic and airway immune responses upon SARS-CoV-2 infection in a clinically well-characterized cohort of 147 infected individuals representing the full spectrum of COVID-19 severity, from asymptomatic infection to fatal disease. In addition, we evaluated how SARS-CoV-2 vaccination influenced the antibody responses in a subset of these individuals during convalescence as compared with naive individuals. Not only systemic but also airway antibody responses correlated with the degree of COVID-19 disease severity. However, although systemic IgG levels were durable for up to 8 months, airway IgG and IgA declined significantly within 3 months. After vaccination, there was an increase in both systemic and airway antibodies, in particular IgG, often exceeding the levels found during acute disease. In contrast, naive individuals showed low airway antibodies after vaccination. In the former COVID-19 patients, airway antibody levels were significantly elevated after the boost vaccination, highlighting the importance of prime and boost vaccinations for previously infected individuals to obtain optimal mucosal protection.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Yu, MengDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Österberg, BjörnKarolinska Institutet
(author)
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Svensson, JuliaKarolinska Institutet
(author)
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Falck-Jones, SaraKarolinska Institutet
(author)
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Vangeti, SindhuDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Åhlberg, EricKarolinska Institutet
(author)
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Azizmohammadi, LidaDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Warnqvist, AnnaKarolinska Institutet
(author)
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Falck-Jones, RyanDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
(author)
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Gubisch, Pia C.Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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Ödemis, MertDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Ghafoor, FarangiesDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Eisele, MonaDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Lenart, KlaraDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Bell, MaxKarolinska Institutet
(author)
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Johansson, NiclasDivision of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital Solna, Stockholm, Sweden
(author)
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Albert, JanKarolinska Institutet
(author)
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Sälde, JörgenNärakut SLSO, Karolinska University Hospital Solna, Stockholm, Sweden
(author)
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Pettie, Deleah D.Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
(author)
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Murphy, Michael P.Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
(author)
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Carter, LaurenDepartment of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
(author)
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King, Neil P.Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States
(author)
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Ols, SebastianKarolinska Institutet
(author)
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Normark, JohanUmeå universitet,Immunologi/immunkemi(Swepub:umu)jono0053
(author)
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Ahlm, Clas,1956-Umeå universitet,Immunologi/immunkemi(Swepub:umu)clah0001
(author)
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Forsell, Mattias N.Umeå universitet,Immunologi/immunkemi(Swepub:umu)mafo0173
(author)
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Färnert, AnnaKarolinska Institutet
(author)
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Loré, KarinKarolinska Institutet
(author)
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Smed-Sörensen, AnnaKarolinska Institutet
(author)
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Karolinska InstitutetDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(creator_code:org_t)
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In:JCI Insight: American Society for Clinical Investigation6:222379-3708
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Cagigi, Alberto
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Yu, Meng
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Österberg, Björn
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Svensson, Julia
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Falck-Jones, Sar ...
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Vangeti, Sindhu
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Åhlberg, Eric
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Azizmohammadi, L ...
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Warnqvist, Anna
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Falck-Jones, Rya ...
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Gubisch, Pia C.
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Ödemis, Mert
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Ghafoor, Farangi ...
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Eisele, Mona
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Lenart, Klara
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Bell, Max
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Johansson, Nicla ...
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Albert, Jan
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Sälde, Jörgen
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Pettie, Deleah D ...
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Murphy, Michael ...
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Carter, Lauren
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King, Neil P.
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Ols, Sebastian
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Normark, Johan
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Ahlm, Clas, 1956 ...
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Forsell, Mattias ...
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Färnert, Anna
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Loré, Karin
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Smed-Sörensen, A ...
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