SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Farnebo Marianne)
 

Search: WFRF:(Farnebo Marianne) > Evaluation of dyske...

  • Ranhem, CeciliaDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Region Västmanland, Uppsala University, Västmanlands Hospital Västerås, Vasteras, Sweden (author)

Evaluation of dyskerin expression and the Cajal body protein WRAP53β as potential prognostic markers for patients with primary vaginal carcinoma

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Spandidos Publications,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-190412
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190412URI
  • https://doi.org/10.3892/OL.2021.13148DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Primary vaginal cancer (PVC) is a rare gynae- cological malignancy, which, at present, lacks appropriate biomarkers for prognosis. The proteins dyskerin and WD repeat containing antisense to TP53 (WRAP53β), both of which exert their functions in the telomerase holoenzyme complex, have been shown to be upregulated in different cancer types. These proteins have also been proposed as prognostic markers in some types of cancer. The aim of the present study was to examine the expression patterns of dyskerin and WRAP53β in patients with PVC. Moreover, as part of a search for effective biomarkers to evaluate prog- nosis in PVC, the expression of these two proteins and their potential association with clinical variables and survival were also evaluated. The expression of dyskerin and WRAP53β was assessed in PVC tumour samples from 68 patients using immunohistochemistry. The majority of tumour samples showed low and moderate expression levels of dyskerin. Upregulation of dyskerin in tumour samples was signifi- cantly associated with a shorter survival time and a poorer cancer-specific survival rate. WRAP53β was also expressed in most of the cells but was not significantly associated with clinical variables or survival. This study demonstrates that upregulation of dyskerin is significantly associated with poor prognosis. Thus, dyskerin may serve as a promising prognostic marker and a potential putative therapeutic target in PVC.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Larsson, Gabriella LillsundeSchool of Health and Medical Sciences, Örebro University, Campus USÖ, Örebro, Sweden; Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden (author)
  • Lindqvist, David,Docent,1981-Umeå universitet,Onkologi(Swepub:umu)dali0066 (author)
  • Sorbe, BengtDepartment of Oncology, Örebro University Hospital, Sweden (author)
  • Karlsson, Mats G.School of Medical Sciences, Örebro University, Örebro, Sweden (author)
  • Farnebo, MarianneDepartment of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden (author)
  • Hellman, KristinaDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden (author)
  • Kovaleska, LarysaR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine (author)
  • Kashuba, ElenaR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine; Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden (author)
  • Andersson, SoniaDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden (author)
  • Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Region Västmanland, Uppsala University, Västmanlands Hospital Västerås, Vasteras, SwedenSchool of Health and Medical Sciences, Örebro University, Campus USÖ, Örebro, Sweden; Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden (creator_code:org_t)

Related titles

  • In:Oncology Letters: Spandidos Publications23:11792-10741792-1082

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view