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Dietary Advanced Gl...
Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
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Aglago, Elom K. (author)
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Mayén, Ana-Lucia (author)
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Knaze, Viktoria (author)
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Freisling, Heinz (author)
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Fedirko, Veronika (author)
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Hughes, David J. (author)
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Jiao, Li (author)
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Eriksen, Anne Kirstine (author)
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Tjønneland, Anne (author)
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Boutron-Ruault, Marie-Christine (author)
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Rothwell, Joseph A. (author)
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Severi, Gianluca (author)
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Kaaks, Rudolf (author)
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Katzke, Verena (author)
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Schulze, Matthias B. (author)
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Birukov, Anna (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Santucci de Magistris, Maria (author)
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Tumino, Rosario (author)
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Ricceri, Fulvio (author)
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Bueno-de-Mesquita, Bas (author)
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Derksen, Jeroen W. G. (author)
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Skeie, Guri (author)
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Gram, Inger Torhild (author)
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Sandanger, Torkjel (author)
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Quirós, J. Ramón (author)
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Luján-Barroso, Leila (author)
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Sánchez, Maria-Jose (author)
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Amiano, Pilar (author)
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Chirlaque, María-Dolores (author)
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Gurrea, Aurelio Barricarte (author)
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- Johansson, Ingegerd (author)
- Umeå universitet,Onkologi
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Manjer, Jonas (author)
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Perez-Cornago, Aurora (author)
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Weiderpass, Elisabete (author)
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Gunter, Marc J. (author)
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Heath, Alicia K. (author)
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Schalkwijk, Casper G. (author)
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Jenab, Mazda (author)
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(creator_code:org_t)
- 2021-09-08
- 2021
- English.
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In: Nutrients. - : MDPI. - 2072-6643. ; 13:9
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- advanced glycation end-products
- colorectal cancer
- dietary exposure
- dietary glycation compounds
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nutrients
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To the university's database
- By the author/editor
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Aglago, Elom K.
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Mayén, Ana-Lucia
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Knaze, Viktoria
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Freisling, Heinz
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Fedirko, Veronik ...
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Hughes, David J.
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show more...
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Jiao, Li
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Eriksen, Anne Ki ...
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Tjønneland, Anne
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Boutron-Ruault, ...
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Rothwell, Joseph ...
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Severi, Gianluca
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Kaaks, Rudolf
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Katzke, Verena
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Schulze, Matthia ...
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Birukov, Anna
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Palli, Domenico
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Sieri, Sabina
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Santucci de Magi ...
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Tumino, Rosario
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Ricceri, Fulvio
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Bueno-de-Mesquit ...
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Derksen, Jeroen ...
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Skeie, Guri
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Gram, Inger Torh ...
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Sandanger, Torkj ...
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Quirós, J. Ramón
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Luján-Barroso, L ...
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Sánchez, Maria-J ...
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Amiano, Pilar
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Chirlaque, María ...
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Gurrea, Aurelio ...
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Johansson, Ingeg ...
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Manjer, Jonas
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Perez-Cornago, A ...
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Weiderpass, Elis ...
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Gunter, Marc J.
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Heath, Alicia K.
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Schalkwijk, Casp ...
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Jenab, Mazda
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Nutrients
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Umeå University