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  • Aglago, Elom K. (author)

Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-09-08
  • MDPI,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-190623
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190623URI
  • https://doi.org/10.3390/nu13093132DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.

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  • Mayén, Ana-Lucia (author)
  • Knaze, Viktoria (author)
  • Freisling, Heinz (author)
  • Fedirko, Veronika (author)
  • Hughes, David J. (author)
  • Jiao, Li (author)
  • Eriksen, Anne Kirstine (author)
  • Tjønneland, Anne (author)
  • Boutron-Ruault, Marie-Christine (author)
  • Rothwell, Joseph A. (author)
  • Severi, Gianluca (author)
  • Kaaks, Rudolf (author)
  • Katzke, Verena (author)
  • Schulze, Matthias B. (author)
  • Birukov, Anna (author)
  • Palli, Domenico (author)
  • Sieri, Sabina (author)
  • Santucci de Magistris, Maria (author)
  • Tumino, Rosario (author)
  • Ricceri, Fulvio (author)
  • Bueno-de-Mesquita, Bas (author)
  • Derksen, Jeroen W. G. (author)
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  • Sánchez, Maria-Jose (author)
  • Amiano, Pilar (author)
  • Chirlaque, María-Dolores (author)
  • Gurrea, Aurelio Barricarte (author)
  • Johansson, IngegerdUmeå universitet,Onkologi(Swepub:umu)injo0003 (author)
  • Manjer, Jonas (author)
  • Perez-Cornago, Aurora (author)
  • Weiderpass, Elisabete (author)
  • Gunter, Marc J. (author)
  • Heath, Alicia K. (author)
  • Schalkwijk, Casper G. (author)
  • Jenab, Mazda (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:Nutrients: MDPI13:92072-6643

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