The Relationship between the Tissue Expression of TLR2, TLR4, TLR5, and TLR7 and Systemic Inflammatory Responses in Colorectal Cancer Patients

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Palmqvist Karin) > (2020-2024) > The Relationship be...

1 of 11
Previous record
Next record
To hitlist

Details
MARC

Beilmann-Lehtonen, Ines (author)

The Relationship between the Tissue Expression of TLR2, TLR4, TLR5, and TLR7 and Systemic Inflammatory Responses in Colorectal Cancer Patients

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021-09-08
S. Karger,2021
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-190660
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190660URI
https://doi.org/10.1159/000518397DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Background: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy globally. CRC patients with elevated plasma C-reactive protein (CRP) levels exhibit compromised prognoses. Toll-like receptors (TLRs), activating the innate and adaptive immune systems, may contribute to pro- and antitumorigenic inflammatory responses. We aimed to identify a possible link between local and systemic inflammatory responses in CRC patients by investigating the association between tissue TLRs and plasma CRP.Methods: Tissue expressions of TLR2, TLR4, TLR5, and TLR7 were assessed using immunohistochemistry of tissue microarray slides from 549 CRC patients surgically treated between 1998 and 2005. Blood samples were drawn preoperatively, centrifuged, aliquoted, and stored at −80°C until analysis. Plasma CRP was determined through high-sensitivity time-resolved immunofluorometric assay. We investigated the association of TLRs to clinicopathologic variables, plasma CRP, and survival.Results: High TLR2 expression (hazard ratio [HR] 0.59; 95% confidence interval [CI] 0.41–0.85; p = 0.005), high TLR5 expression (HR 0.60; 95% CI 0.45–0.83; p = 0.002), positive TLR7 expression (HR 0.49; 95% CI 0.33–0.72; p < 0.001), and low CRP (HR 1.48; 95% CI 1.08–2.11; p = 0.017) were associated with a better prognosis. A high TLR2 immunoexpression was associated with a better prognosis among low-CRP patients (HR 0.53; 95% CI 0.35–0.80; p = 0.002), high TLR4 expression among high-CRP patients (HR 2.04; 95% CI 1.04–4.00; p = 0.038), high TLR5 expression among low-CRP patients (HR 0.059; 95% CI 0.37–0.92; p = 0.021), and positive TLR7 expression among low-CRP patients (HR 0.53; 95% CI 0.28–1.00; p = 0.049). In multivariate analyses, no biomarkers emerged as significant independent variables.Conclusions: High tissue TLR2, TLR5, and TLR7 levels were associated with a better prognosis. Among low-CRP patients, those with high TLR2, TLR5, and TLR7 immunoexpressions exhibited a better prognosis. Among high CRP patients, a high TLR4 immunoexpression was associated with a better prognosis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Colorectal cancer
Immunohistochemistry
Prognosis
Survival
Toll-like receptor

Added entries (persons, corporate bodies, meetings, titles ...)

Hagström, Jaana (author)
Kaprio, Tuomas (author)
Stenman, Ulf-Håkan (author)
Strigård, KarinUmeå universitet,Kirurgi,Clister(Swepub:umu)kast0065 (author)
Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001 (author)
Gunnarsson, UlfUmeå universitet,Kirurgi,Clister(Swepub:umu)ulgu0014 (author)
Böckelman, Camilla (author)
Haglund, Caj (author)
Umeå universitetKirurgi (creator_code:org_t)

Related titles

In:Oncology: S. Karger99:12, s. 790-8010030-24141423-0232

Internet link

Find in a library

Oncology (Search for host publication in LIBRIS)

To the university's database

1 of 11
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Beilmann-Lehtone ...; Hagström, Jaana; Kaprio, Tuomas; Stenman, Ulf-Håk ...; Strigård, Karin; Palmqvist, Richa ...; show more...; Gunnarsson, Ulf; Böckelman, Camil ...; Haglund, Caj; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Oncology

By the university: Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se