Sökning: onr:"swepub:oai:DiVA.org:umu-19081" >
The Gly482Ser genot...
-
Vimaleswaran, Karani Santhanakrishnan
(författare)
The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure : a meta-analysis involving 13,949 individuals
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
-
Bethesda :American physiological society,2008
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-19081
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19081URI
-
https://doi.org/10.1152/japplphysiol.90423.2008DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The protein encoded by the PPARGC1A gene is expressed at high levels in metabolically active tissues and is involved in the control of oxidative stress via reactive oxygen species detoxification. Several recent reports suggest that the PPARGC1A Gly482Ser (rs8192678) missense polymorphism may relate inversely with blood pressure. We used conventional meta-analysis methods to assess the association between Gly482Ser and systolic (SBP) or diastolic blood pressures (DBP) or hypertension in 13,949 individuals from 17 studies, of which 6,042 were previously unpublished observations. The studies comprised cohorts of white European, Asian, and American Indian adults, and adolescents from South America. Stratified analyses were conducted to control for population stratification. Pooled genotype frequencies were 0.47 (Gly482Gly), 0.42 (Gly482Ser), and 0.11 (Ser482Ser). We found no evidence of association between Gly482Ser and SBP [Gly482Gly: mean = 131.0 mmHg, 95% confidence interval (CI) = 130.5-131.5 mmHg; Gly482Ser mean = 133.1 mmHg, 95% CI = 132.6-133.6 mmHg; Ser482Ser: mean = 133.5 mmHg, 95% CI = 132.5-134.5 mmHg; P = 0.409] or DBP (Gly482Gly: mean = 80.3 mmHg, 95% CI = 80.0-80.6 mmHg; Gly482Ser mean = 81.5 mmHg, 95% CI = 81.2-81.8 mmHg; Ser482Ser: mean = 82.1 mmHg, 95% CI = 81.5-82.7 mmHg; P = 0.651). Contrary to previous reports, we did not observe significant effect modification by sex (SBP, P = 0.966; DBP, P = 0.715). We were also unable to confirm the previously reported association between the Ser482 allele and hypertension [odds ratio: 0.97, 95% CI = 0.87-1.08, P = 0.585]. These results were materially unchanged when analyses were focused on whites only. However, statistical evidence of gene-age interaction was apparent for DBP [Gly482Gly: 73.5 (72.8, 74.2), Gly482Ser: 77.0 (76.2, 77.8), Ser482Ser: 79.1 (77.4, 80.9), P = 4.20 x 10(-12)] and SBP [Gly482Gly: 121.4 (120.4, 122.5), Gly482Ser: 125.9 (124.6, 127.1), Ser482Ser: 129.2 (126.5, 131.9), P = 7.20 x 10(-12)] in individuals <50 yr (n = 2,511); these genetic effects were absent in those older than 50 yr (n = 5,088) (SBP, P = 0.41; DBP, P = 0.51). Our findings suggest that the PPARGC1A Ser482 allele may be associated with higher blood pressure, but this is only apparent in younger adults.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Luan, Jian'an
(författare)
-
Andersen, Gitte
(författare)
-
Muller, Y Li
(författare)
-
Wheeler, Eleanor
(författare)
-
Brito, Ema CUmeå universitet,Medicin
(författare)
-
O'Rahilly, Stephen
(författare)
-
Pedersen, Oluf
(författare)
-
Baier, Leslie J
(författare)
-
Knowler, William C
(författare)
-
Barroso, Inês
(författare)
-
Wareham, Nicholas J
(författare)
-
Loos, Ruth J F
(författare)
-
Franks, Paul WUmeå universitet,Medicin,Medical Research Council, Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom(Swepub:umu)pafr0003
(författare)
-
Umeå universitetMedicin
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of applied physiologyBethesda : American physiological society105:4, s. 1352-13588750-75871522-1601
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Vimaleswaran, Ka ...
-
Luan, Jian'an
-
Andersen, Gitte
-
Muller, Y Li
-
Wheeler, Eleanor
-
Brito, Ema C
-
visa fler...
-
O'Rahilly, Steph ...
-
Pedersen, Oluf
-
Baier, Leslie J
-
Knowler, William ...
-
Barroso, Inês
-
Wareham, Nichola ...
-
Loos, Ruth J F
-
Franks, Paul W
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Fysiologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Idrottsvetenskap
- Artiklar i publikationen
-
Journal of appli ...
- Av lärosätet
-
Umeå universitet