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Biomarkers predict ...
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Henein, Michael Y.Umeå universitet,Avdelningen för medicin,St George London and Brunel Universities, London, United Kingdom
(författare)
Biomarkers predict in-hospital major adverse cardiac events in covid-19 patients : A multicenter international study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-12-14
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MDPI,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-190815
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190815URI
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https://doi.org/10.3390/jcm10245863DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148591610URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: The COVID-19 pandemic carries a high burden of morbidity and mortality worldwide. We aimed to identify possible predictors of in-hospital major cardiovascular (CV) events in COVID-19.Methods: We retrospectively included patients hospitalized for COVID-19 from 10 centers. Clinical, biochemical, electrocardiographic, and imaging data at admission and medications were collected. Primary endpoint was a composite of in-hospital CV death, acute heart failure (AHF), acute myocarditis, arrhythmias, acute coronary syndromes (ACS), cardiocirculatory arrest, and pulmonary embolism (PE).Results: Of the 748 patients included, 141(19%) reached the set endpoint: 49 (7%) CV death, 15 (2%) acute myocarditis, 32 (4%) sustained-supraventricular or ventricular arrhythmias, 14 (2%) cardiocirculatory arrest, 8 (1%) ACS, 41 (5%) AHF, and 39 (5%) PE. Patients with CV events had higher age, body temperature, creatinine, high-sensitivity troponin, white blood cells, and platelet counts at admission and were more likely to have systemic hypertension, renal failure (creatinine ≥ 1.25 mg/dL), chronic obstructive pulmonary disease, atrial fibrillation, and cardiomyopathy. On univariate and multivariate analysis, troponin and renal failure were associated with the composite endpoint. Kaplan–Meier analysis showed a clear divergence of in-hospital composite event-free survival stratified according to median troponin value and the presence of renal failure (Log rank p < 0.001).Conclusions: Our findings, derived from a multicenter data collection study, suggest the routine use of biomarkers, such as cardiac troponin and serum creatinine, for in-hospital prediction of CV events in patients with COVID-19.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mandoli, Giulia ElenaDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
(författare)
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Pastore, Maria ConcettaDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
(författare)
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Ghionzoli, NicolòDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
(författare)
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Hasson, FouhadLuton and Dunstable University Hospital, NHS Foundation Trust, Luton, United Kingdom
(författare)
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Nisar, Muhammad K.Luton and Dunstable University Hospital, NHS Foundation Trust, Luton, United Kingdom
(författare)
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Islam, MohammedLuton and Dunstable University Hospital, NHS Foundation Trust, Luton, United Kingdom
(författare)
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Bandera, FrancescoDepartment for Biomedical Sciences for Health, University of Milano, Milan, Italy; Cardiology University Department, Heart Failure Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
(författare)
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Marrocco-Trischitta, Massimiliano M.Clinical Research Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
(författare)
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Baroni, IreneClinical Research Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
(författare)
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Malagoli, AlessandroDivision of Cardiology, Nephro-Cardiovascular Department, Baggiovara Hospital, University of Modena and Reggio Emilia, Modena, Italy
(författare)
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Rossi, LucaDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy
(författare)
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Biagi, AndreaDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy
(författare)
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Citro, RodolfoCardio-Thoracic-Vascular Department, University Hospital San Giovanni di Dio e Ruggi d’Aragona, Salerno, Italy
(författare)
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Ciccarelli, MicheleDepartment of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy
(författare)
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Silverio, AngeloDepartment of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy
(författare)
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Biagioni, GiuliaDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
(författare)
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Moutiris, Joseph A.Paphos Hospital, University of Nicosia, Nicosia, Cyprus
(författare)
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Vancheri, FedericoDepartment of Internal Medicine, S. Elia Hospital, Caltanissetta, Italy
(författare)
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Mazzola, GiovanniDepartment of Internal Medicine, S. Elia Hospital, Caltanissetta, Italy
(författare)
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Geraci, GiulioDepartment of Internal Medicine, S. Elia Hospital, Caltanissetta, Italy
(författare)
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Thomas, LizaDepartment of Cardiology, Westmead Hospital and Westmeead Clinical School, University of Sydney, NSW, Sydney, Australia
(författare)
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Altman, MikhailDepartment of Cardiology, Westmead Hospital and Westmeead Clinical School, University of Sydney, NSW, Sydney, Australia
(författare)
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Pernow, JohnKarolinska Institutet
(författare)
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Ahmed, MonaDepartment of Molecular Medicine and Surgery, Division of Cardiology, Karolinska Institutet, Stockholm, Sweden
(författare)
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Santoro, CiroDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, Naples, Italy
(författare)
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Esposito, RobertaDepartment of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy
(författare)
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Casas, GuillemDepartment of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
(författare)
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Fernández-Galera, RubénDepartment of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
(författare)
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Gonzalez, MaribelDepartment of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
(författare)
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Palomares, Jose RodriguezDepartment of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
(författare)
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Bytyci, IbadeteUmeå universitet,Avdelningen för medicin,Clinic of Cardiology, University Clinical Centre of Kosova, Prishtina Kosovo(Swepub:umu)ibby0002
(författare)
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Dini, Frank LloydUmeå universitet,Avdelningen för medicin
(författare)
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Cameli, PaoloRespiratory Diseases Unit, Department of Medical Sciences, Siena University Hospital, Siena, Italy
(författare)
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Franchi, FedericoDepartment of Medical Biotechnologies, Anesthesia and Intensive Care, University of Siena, Siena, Italy
(författare)
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Bajraktari, GaniUmeå universitet,Avdelningen för medicin,Clinic of Cardiology, University Clinical Centre of Kosova, Prishtina Kosovo; Medical Faculty, University of Prishtina “Hasan Prishtina”, Prishtina Kosovo(Swepub:umu)gaba0006
(författare)
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Badano, Luigi PaoloIstituto Auxologico Italiano, IRCCS, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
(författare)
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Cameli, MatteoDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
(författare)
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Umeå universitetAvdelningen för medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical Medicine: MDPI10:242077-0383
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Henein, Michael ...
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Mandoli, Giulia ...
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Pastore, Maria C ...
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Ghionzoli, Nicol ...
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Hasson, Fouhad
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Nisar, Muhammad ...
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visa fler...
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Islam, Mohammed
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Bandera, Frances ...
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Marrocco-Trischi ...
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Baroni, Irene
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Malagoli, Alessa ...
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Rossi, Luca
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Biagi, Andrea
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Citro, Rodolfo
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Ciccarelli, Mich ...
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Silverio, Angelo
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Biagioni, Giulia
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Moutiris, Joseph ...
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Vancheri, Federi ...
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Mazzola, Giovann ...
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Geraci, Giulio
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Thomas, Liza
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Altman, Mikhail
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Pernow, John
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Ahmed, Mona
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Santoro, Ciro
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Esposito, Robert ...
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Casas, Guillem
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Fernández-Galera ...
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Gonzalez, Maribe ...
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Palomares, Jose ...
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Bytyci, Ibadete
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Dini, Frank Lloy ...
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Cameli, Paolo
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Franchi, Federic ...
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Bajraktari, Gani
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Badano, Luigi Pa ...
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Cameli, Matteo
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of Clini ...
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Umeå universitet
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Karolinska Institutet