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Biomarkers predict in-hospital major adverse cardiac events in covid-19 patients : A multicenter international study
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- Henein, Michael Y. (författare)
- Umeå universitet,Avdelningen för medicin,St George London and Brunel Universities, London, United Kingdom
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- Mandoli, Giulia Elena (författare)
- Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
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- Pastore, Maria Concetta (författare)
- Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
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- Ghionzoli, Nicolò (författare)
- Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
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- Hasson, Fouhad (författare)
- Luton and Dunstable University Hospital, NHS Foundation Trust, Luton, United Kingdom
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- Nisar, Muhammad K. (författare)
- Luton and Dunstable University Hospital, NHS Foundation Trust, Luton, United Kingdom
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- Islam, Mohammed (författare)
- Luton and Dunstable University Hospital, NHS Foundation Trust, Luton, United Kingdom
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- Bandera, Francesco (författare)
- Department for Biomedical Sciences for Health, University of Milano, Milan, Italy; Cardiology University Department, Heart Failure Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
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- Marrocco-Trischitta, Massimiliano M. (författare)
- Clinical Research Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
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- Baroni, Irene (författare)
- Clinical Research Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
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- Malagoli, Alessandro (författare)
- Division of Cardiology, Nephro-Cardiovascular Department, Baggiovara Hospital, University of Modena and Reggio Emilia, Modena, Italy
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- Rossi, Luca (författare)
- Division of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy
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- Biagi, Andrea (författare)
- Division of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy
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- Citro, Rodolfo (författare)
- Cardio-Thoracic-Vascular Department, University Hospital San Giovanni di Dio e Ruggi d’Aragona, Salerno, Italy
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- Ciccarelli, Michele (författare)
- Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy
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- Silverio, Angelo (författare)
- Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy
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- Biagioni, Giulia (författare)
- Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
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- Moutiris, Joseph A. (författare)
- Karolinska Institutet
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- Vancheri, Federico (författare)
- Department of Internal Medicine, S. Elia Hospital, Caltanissetta, Italy
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- Mazzola, Giovanni (författare)
- Department of Internal Medicine, S. Elia Hospital, Caltanissetta, Italy
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- Geraci, Giulio (författare)
- Department of Internal Medicine, S. Elia Hospital, Caltanissetta, Italy
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- Thomas, Liza (författare)
- Department of Cardiology, Westmead Hospital and Westmeead Clinical School, University of Sydney, NSW, Sydney, Australia
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- Altman, Mikhail (författare)
- Department of Cardiology, Westmead Hospital and Westmeead Clinical School, University of Sydney, NSW, Sydney, Australia
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- Pernow, John (författare)
- Karolinska Institutet
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- Ahmed, Mona (författare)
- Department of Molecular Medicine and Surgery, Division of Cardiology, Karolinska Institutet, Stockholm, Sweden
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- Santoro, Ciro (författare)
- Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Naples, Italy
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- Esposito, Roberta (författare)
- Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy
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- Casas, Guillem (författare)
- Department of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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- Fernández-Galera, Rubén (författare)
- Department of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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- Gonzalez, Maribel (författare)
- Department of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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- Palomares, Jose Rodriguez (författare)
- Department of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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- Bytyci, Ibadete (författare)
- Umeå universitet,Avdelningen för medicin,Clinic of Cardiology, University Clinical Centre of Kosova, Prishtina Kosovo
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- Dini, Frank Lloyd (författare)
- Umeå universitet,Avdelningen för medicin
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- Cameli, Paolo (författare)
- Respiratory Diseases Unit, Department of Medical Sciences, Siena University Hospital, Siena, Italy
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- Franchi, Federico (författare)
- Department of Medical Biotechnologies, Anesthesia and Intensive Care, University of Siena, Siena, Italy
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- Bajraktari, Gani (författare)
- Umeå universitet,Avdelningen för medicin,Clinic of Cardiology, University Clinical Centre of Kosova, Prishtina Kosovo; Medical Faculty, University of Prishtina “Hasan Prishtina”, Prishtina Kosovo
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- Badano, Luigi Paolo (författare)
- Istituto Auxologico Italiano, IRCCS, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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- Cameli, Matteo (författare)
- Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
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(creator_code:org_t)
- 2021-12-14
- 2021
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:24
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The COVID-19 pandemic carries a high burden of morbidity and mortality worldwide. We aimed to identify possible predictors of in-hospital major cardiovascular (CV) events in COVID-19.Methods: We retrospectively included patients hospitalized for COVID-19 from 10 centers. Clinical, biochemical, electrocardiographic, and imaging data at admission and medications were collected. Primary endpoint was a composite of in-hospital CV death, acute heart failure (AHF), acute myocarditis, arrhythmias, acute coronary syndromes (ACS), cardiocirculatory arrest, and pulmonary embolism (PE).Results: Of the 748 patients included, 141(19%) reached the set endpoint: 49 (7%) CV death, 15 (2%) acute myocarditis, 32 (4%) sustained-supraventricular or ventricular arrhythmias, 14 (2%) cardiocirculatory arrest, 8 (1%) ACS, 41 (5%) AHF, and 39 (5%) PE. Patients with CV events had higher age, body temperature, creatinine, high-sensitivity troponin, white blood cells, and platelet counts at admission and were more likely to have systemic hypertension, renal failure (creatinine ≥ 1.25 mg/dL), chronic obstructive pulmonary disease, atrial fibrillation, and cardiomyopathy. On univariate and multivariate analysis, troponin and renal failure were associated with the composite endpoint. Kaplan–Meier analysis showed a clear divergence of in-hospital composite event-free survival stratified according to median troponin value and the presence of renal failure (Log rank p < 0.001).Conclusions: Our findings, derived from a multicenter data collection study, suggest the routine use of biomarkers, such as cardiac troponin and serum creatinine, for in-hospital prediction of CV events in patients with COVID-19.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Biomarkers
- COVID-19
- Creatinine
- Prognosis
- SARS-CoV2
- Troponin
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Henein, Michael ...
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Mandoli, Giulia ...
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Pastore, Maria C ...
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Ghionzoli, Nicol ...
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Hasson, Fouhad
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Nisar, Muhammad ...
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visa fler...
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Islam, Mohammed
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Bandera, Frances ...
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Marrocco-Trischi ...
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Baroni, Irene
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Malagoli, Alessa ...
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Rossi, Luca
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Biagi, Andrea
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Citro, Rodolfo
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Ciccarelli, Mich ...
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Silverio, Angelo
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Biagioni, Giulia
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Moutiris, Joseph ...
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Vancheri, Federi ...
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Mazzola, Giovann ...
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Geraci, Giulio
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Thomas, Liza
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Altman, Mikhail
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Pernow, John
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Ahmed, Mona
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Santoro, Ciro
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Esposito, Robert ...
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Casas, Guillem
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Fernández-Galera ...
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Gonzalez, Maribe ...
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Palomares, Jose ...
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Bytyci, Ibadete
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Dini, Frank Lloy ...
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Cameli, Paolo
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Franchi, Federic ...
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Bajraktari, Gani
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Badano, Luigi Pa ...
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Cameli, Matteo
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet