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Novel Biomarkers of...
Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality
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- Loftfield, Erikka (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Stepien, Magdalena (author)
- Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Viallon, Vivian (author)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Trijsburg, Laura (author)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Rothwell, Joseph A. (author)
- Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France; Gustave Roussy, Villejuif, France; Biomarkers Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Robinot, Nivonirina (author)
- Centre for Epidemiology and Population Health (U1018), Generations and Health team, UVSQ, INSERM, Faculté de Médecine ,Université Paris-Saclay, Villejuif, France
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- Biessy, Carine (author)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Bergdahl, Ingvar (author)
- Umeå University,Umeå universitet,Enheten för biobanksforskning
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- Bodén, Stina (author)
- Umeå University,Umeå universitet,Onkologi
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Bergman, Manuela (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
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- Schmidt, Julie A. (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Zamora-Ros, Raul (author)
- Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain,Catalan Institute of Oncology-Girona
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- Nøst, Therese H. (author)
- Department of Community Medicine, UiT- The Arctic University of Norway, Tromsø, Norway
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- Sandanger, Torkjel M. (author)
- Department of Community Medicine, UiT- The Arctic University of Norway, Tromsø, Norway
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Katzke, Verena (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Kaaks, Rudolf (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Ricceri, Fulvio (author)
- Department of Clinical and Biological Sciences, University of Turin, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco, TO, Italy
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center; University of Copenhagen, Department of Public Health
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- Dahm, Christina C. (author)
- Department of Public Health, Aarhus University, Denmark
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- Sánchez, Maria-Jose (author)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP)
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens, Greece
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- Tumino, Rosario (author)
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
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- Chirlaque, María-Dolores (author)
- Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Masala, Giovanna (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy
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- Ardanaz, Eva (author)
- Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain,Hospital of Navarra, Pamplona
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- Vermeulen, Roel (author)
- Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, Netherlands
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- Brennan, Paul (author)
- Genetic Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Albanes, Demetrius (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Weinstein, Stephanie J. (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Scalbert, Augustin (author)
- Centre for Epidemiology and Population Health (U1018), Generations and Health team, UVSQ, INSERM, Faculté de Médecine ,Université Paris-Saclay, Villejuif, France
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- Freedman, Neal D. (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Gunter, Marc J. (author)
- Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Jenab, Mazda (author)
- Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Sinha, Rashmi (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Keski-Rahkonen, Pekka (author)
- Centre for Epidemiology and Population Health (U1018), Generations and Health team, UVSQ, INSERM, Faculté de Médecine ,Université Paris-Saclay, Villejuif, France
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- Ferrari, Pietro (author)
- Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2021-05-19
- 2021
- English.
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In: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 113:11, s. 1542-1550
- Related links:
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https://digibug.ugr....
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- BACKGROUND: Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed because of measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.METHODS: Untargeted metabolomics was used to identify metabolites correlated with self-reported habitual alcohol intake in a discovery dataset from the European Prospective Investigation into Cancer and Nutrition (EPIC; n = 454). Statistically significant correlations were tested in independent datasets of controls from case-control studies nested within EPIC (n = 280) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC; n = 438) study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations of alcohol-associated metabolites and self-reported alcohol intake with risk of pancreatic cancer, hepatocellular carcinoma (HCC), liver cancer, and liver disease mortality in the contributing studies.RESULTS: Two metabolites displayed a dose-response association with self-reported alcohol intake: 2-hydroxy-3-methylbutyric acid and an unidentified compound. A 1-SD (log2) increase in levels of 2-hydroxy-3-methylbutyric acid was associated with risk of HCC (OR = 2.54, 95% CI = 1.51 to 4.27) and pancreatic cancer (OR = 1.43, 95% CI = 1.03 to 1.99) in EPIC and liver cancer (OR = 2.00, 95% CI = 1.44 to 2.77) and liver disease mortality (OR = 2.16, 95% CI = 1.63 to 2.86) in ATBC. Conversely, a 1-SD (log2) increase in questionnaire-derived alcohol intake was not associated with HCC or pancreatic cancer in EPIC or liver cancer in ATBC but was associated with liver disease mortality (OR = 2.19, 95% CI = 1.60 to 2.98) in ATBC.CONCLUSIONS: 2-hydroxy-3-methylbutyric acid is a candidate biomarker of habitual alcohol intake that may advance the study of alcohol and cancer risk in population-based studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Loftfield, Erikk ...
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Stepien, Magdale ...
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Viallon, Vivian
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Trijsburg, Laura
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Rothwell, Joseph ...
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Robinot, Nivonir ...
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Biessy, Carine
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Bergdahl, Ingvar
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Bodén, Stina
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Schulze, Matthia ...
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Bergman, Manuela
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Weiderpass, Elis ...
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Schmidt, Julie A ...
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Zamora-Ros, Raul
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Nøst, Therese H.
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Sandanger, Torkj ...
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Sonestedt, Emily
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Ohlsson, Bodil
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Katzke, Verena
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Kaaks, Rudolf
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Ricceri, Fulvio
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Tjønneland, Anne
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Dahm, Christina ...
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Sánchez, Maria-J ...
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Trichopoulou, An ...
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Tumino, Rosario
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Chirlaque, María ...
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Masala, Giovanna
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Ardanaz, Eva
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Vermeulen, Roel
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Brennan, Paul
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Albanes, Demetri ...
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Weinstein, Steph ...
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Scalbert, August ...
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Freedman, Neal D ...
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Gunter, Marc J.
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Jenab, Mazda
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Sinha, Rashmi
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Keski-Rahkonen, ...
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Ferrari, Pietro
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Umeå University
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Lund University