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Sökning: WFRF:(Canzian Federico) > (2020-2023) > Are Circulating Imm...

Are Circulating Immune Cells a Determinant of Pancreatic Cancer Risk? A Prospective Study Using Epigenetic Cell Count Measures

Katzke, Verena A. (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Le Cornet, Charlotte (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Mahfouz, Rayaan (författare)
Ivana Turbachova € Laboratory for Epigenetics, Epiontis GmbH, Precision for Medicine Group, Berlin, Germany
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Brauer, Bianca (författare)
Ivana Turbachova € Laboratory for Epigenetics, Epiontis GmbH, Precision for Medicine Group, Berlin, Germany
Johnson, Theron (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Canzian, Federico (författare)
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
Rebours, Vinciane (författare)
Pancrea-tology Department, Beaujon Hospital, AP-HP, Clichy, France; Inserm, UMR1149, DHU Unit, Paris-Diderot University, Paris, France
Boutron-Ruault, Marie-Christine (författare)
Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, “Exposome and Heredity” team, CESP, Villejuif, France
Severi, Gianluca (författare)
Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, “Exposome and Heredity” team, CESP, Villejuif, France; Department of Statistics, Computer Science and Applications “G. Parenti,”, University of Florence, Florence, Italy
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Olsen, Anja (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Århus, Arhus, Denmark
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Overvad, Kim (författare)
Department of Public Health, University of Århus, Arhus, Denmark
Crous-Bou, Marta (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL)., L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Molina-Montes, Esther (författare)
Department of Nutrition and Food Sciences, Faculty of Pharmacy, University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria (ibs.GRANADA), Granada, Spain; CIBERESP, Madrid, Spain; Institute of Nutrition and Food Technology “Jose Mataix,”, Center of Biomedical Research, University of Granada, Granada, Spain
Amiano, Pilar (författare)
CIBERESP, Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain
Huerta, Jose María (författare)
CIBERESP, Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
Ardanaz, Eva (författare)
CIBERESP, Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Masala, Giovanna (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
Pala, Valeria (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
Sacerdote, Carlotta (författare)
Unit of Cancer Epidemiology, Citta della Salute e della Scienza University-Hospital, Turin, Italy
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Bueno-De-Mesquita, Bas (författare)
Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven, Netherlands
Vermeulen, Roel (författare)
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; School of Public Health, Imperial College London, London, United Kingdom
Sund, Malin (författare)
Umeå universitet,Kirurgi
Franklin, Oskar, 1985- (författare)
Umeå universitet,Kirurgi
Christakoudi, Sofia (författare)
School of Public Health, Imperial College London, London, United Kingdom; Department of Epidemiology and Biostatistics, Imperial College London, St Mary’s Campus, Norfolk Place, London, United Kingdom; MRC Centre for Transplantation, King’s College London, Great Maze Pond, London, United Kingdom
Dossus, Laure (författare)
International Agency for Research on Cancer, World Health Organization, Lyon, France
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization, Lyon, France
Olek, Sven (författare)
Ivana Turbachova € Laboratory for Epigenetics, Epiontis GmbH, Precision for Medicine Group, Berlin, Germany
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), Heidelberg, Germany
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 (creator_code:org_t)
American Association for Cancer Research (AACR), 2021
2021
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 30:12, s. 2179-2187
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Evidence is accumulating that immune cells play a prominent role in pancreatic cancer etiology but prospective investigations are missing.Methods: We conducted a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sublineages: total CD3+, CD8+, CD4+, and FOXP3+ regulatory T cells (Tregs) relative to nucleated cells, (white blood cells) were measured by qRT-PCR. ORs with 95% confidence intervals were estimated using logistic regressions, modeling relative counts of immune cells on a continuous scale.Results: Neither relative counts of immune cell types taken individually, nor mutually adjusted for each other were associated with pancreatic cancer risks. However, in subgroup analyses by strata of lag-time, higher relative counts of Tregs and lower relative counts of CD8+ were significantly associated with an increased pancreatic cancer risks in participants diagnosed within the first 5 years of follow-up.Conclusions: These results might reflect reverse causation, due to higher relative counts of Tregs and lower counts of CD8+ cells among individuals with more advanced stages of latent pancreatic cancer, who are closer to the point of developing clinical manifest disease.Impact: We have shown, for the first time, that increased relative counts of regulatory T cells and lower relative counts of CD8+, cytotoxic T cells may be associated with pancreatic cancer risk or relatively late-stage tumor development. See related commentary by Michaud and Kelsey, p. 2176

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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