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Epitranscriptomic mechanisms of androgen signalling and prostate cancer

Patke, Rodhan (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Harris, Anna E. (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Woodcock, Corinne L. (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
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Thompson, Rachel (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Santos, Rute (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Kumari, Amber (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom
Allegrucci, Cinzia (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Archer, Nathan (författare)
School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Gudas, Lorraine J. (författare)
Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States
Robinson, Brian D. (författare)
Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States
Persson, Jenny L., Professor (författare)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
Fray, Rupert (författare)
School of Biosciences, University of Nottingham, United Kingdom
Jeyapalan, Jennie (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Rutland, Catrin S. (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
Rakha, Emad (författare)
School of Medicine, University of Nottingham, United Kingdom; Nottingham University NHS Trust, Nottingham, United Kingdom
Madhusudan, Srinivasan (författare)
School of Medicine, University of Nottingham, United Kingdom; Nottingham University NHS Trust, Nottingham, United Kingdom
Emes, Richard D. (författare)
Research and Innovation, Nottingham Trent University, United Kingdom
Muyangwa-Semenova, Musalwa (författare)
University of Zambia, Lukasa, Zambia
Alsaleem, Mansour (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; Unit of Scientific Research, Applied College, Qassim University, Qassim, Saudi Arabia
de Brot, Simone (författare)
Institute of Animal Pathology, University of Bern, Switzerland
Green, William (författare)
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
Ratan, Hari (författare)
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
Mongan, Nigel P. (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom; Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States
Lothion-Roy, Jennifer (författare)
Biodiscovery Institute, University of Nottingham, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: Neoplasia. - : Elsevier. - 1522-8002 .- 1476-5586. ; 56
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen hormones play an essential role in prostate carcinogenesis and progression, androgen deprivation therapy (ADT) is often used to deprive PCa cells of the pro-proliferative effect of androgens. ADTs act by either blocking androgen biosynthesis (e.g. abiraterone) or blocking AR function (e.g. bicalutamide, enzalutamide, apalutamide, darolutamide). ADT is often effective in initially suppressing PCa growth and progression, yet emergence of castrate-resistant PCa and progression to neuroendocrine-like PCa following ADT are major clinical challenges. For this reason, there is an urgent need to identify novel approaches to modulate androgen signalling to impede PCa progression whilst also preventing or delaying therapy resistance. The mechanistic convergence of androgen and epitranscriptomic signalling offers a potential novel approach to treat PCa. The epitranscriptome involves covalent modifications of mRNA, notably, in the context of this review, the N(6)-methyladenosine (m6A) modification. m6A is involved in the regulation of mRNA splicing, stability, and translation, and has recently been shown to play a role in PCa and androgen signalling. The m6A modification is dynamically regulated by the METTL3-containing methyltransferase complex, and the FTO and ALKBH5 RNA demethylases. Given the need for novel approaches to treat PCa, there is significant interest in new therapies that target m6A that modulate AR expression and androgen signalling. This review critically summarises the potential benefit of such epitranscriptomic therapies for PCa patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

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  • Neoplasia (Sök värdpublikationen i LIBRIS)

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