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Sökning: id:"swepub:oai:DiVA.org:umu-191071" > Pretreatment With P...

  • Jurga, JulianeKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)

Pretreatment With P2Y12 Inhibitors in Patients With Chronic Coronary Syndrome Undergoing Percutaneous Coronary Intervention : A Report From the Swedish Coronary Angiography and Angioplasty Registry

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • NLM (Medline),2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-191071
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191071URI
  • https://doi.org/10.1161/CIRCINTERVENTIONS.121.010849DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148727705URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-182943URI
  • https://gup.ub.gu.se/publication/308052URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: In patients with chronic coronary syndrome undergoing percutaneous coronary intervention, the optimal timing of P2Y12 inhibitors' administration is uncertain. We compared pretreatment versus treatment in the catheterization laboratory (In-Cathlab) in a real-world population.METHODS: In Swedish Coronary Angiography and Angioplasty Registry, all patients with chronic coronary syndrome undergoing coronary angiography and ad hoc percutaneous coronary intervention, between 2006 and 2017 were identified. Pretreatment was defined as P2Y12 inhibitor administration before coronary angiography, outside the catheterization laboratory. Outcomes were net adverse clinical events including death, myocardial infarction, stroke, or bleeding within 30 days of the index procedure and in-hospital bleeding.RESULTS: We included 26 814 patients, 8237 in the In-Cathlab, and 18 577 in the pretreatment group. In-Cathlab treatment compared with pretreatment was associated with lower risk for net adverse clinical event (4.2 versus 5.1%, adjusted hazard ratio 0.79 [0.63-0.99]), bleeding (2.3 versus 2.6%, adjusted hazard ratio, 0.76 [0.57-1.01]). and in-hospital bleeding (1.9 versus 2.1%, adjusted odds ratio, 0.70 [0.51-0.96]). The risk for death, myocardial infarction, or stroke did not significantly differ between the groups. Among the In-Cathlab treated patients, 41% received ticagrelor or prasugrel and 59% clopidogrel. Treatment with ticagrelor or prasugrel was associated with higher risk for net adverse clinical events (5.4% versus 3.4%, adjusted hazard ratio, 1.66 [1.12-2.48]), bleeding (3.4 versus 1.6%, adjusted hazard ratio, 2.14 [1.34-3.42]), and in-hospital bleeding (2.9 versus 1.2%, adjusted odds ratio, 2.24 [1.29-3.90]) but similar risk for death, myocardial infarction, or stroke, compared with clopidogrel.CONCLUSIONS: In patients with chronic coronary syndrome undergoing coronary angiography and ad hoc percutaneous coronary intervention, pretreatment with P2Y12 inhibitors, before arrival to the catheterization laboratory, was not associated with improved clinical outcomes but was associated with increased risk for bleeding. Our data support clopidogrel administration in the catheterization laboratory as the standard of care. Graphic Abstract: A graphic abstract is available for this article.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Szummer, Karolina ElizabethDepartment of Cardiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Huddinge, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Lewinter, ChristianDepartment of Cardiology, Karolinska Institutet and Karolinska University Hospital, C.L., L.M., Stockholm, Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Mellbin, LindaKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Götberg, MatthiasDepartment of Cardiology, Lund University Hospital, Skåne, Sweden,Lund Univ Hosp, Sweden (författare)
  • Zwackman, SammyLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)samzw44 (författare)
  • Nilsson, JohanUmeå universitet,Kardiologi,Department of Cardiology, Umeå University and Umeå University Hospital,Umea Univ, Sweden; Umea Univ Hosp, Sweden(Swepub:umu)joni0050 (författare)
  • Völz, Sebastian,1980Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xvolse (författare)
  • Erlinge, DavidDepartment of Cardiology, Lund University Hospital, Skåne, Sweden,Lund Univ Hosp, Sweden (författare)
  • Persson, JonasDepartment of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden,Danderyd Hosp, Sweden (författare)
  • Omerovic, Elmir,1968Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xomeel (författare)
  • Jernberg, TomasKarolinska Institutet,Danderyd Hosp, Sweden (författare)
  • Venetsanos, DimitriosDepartment of Cardiology, Karolinska Institutet and Karolinska University Hospital, C.L., L.M., Stockholm, Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Karolinska InstitutetKarolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Circulation. Cardiovascular Interventions: NLM (Medline)14:11, s. 1086-10931941-76401941-7632

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