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Sökning: WFRF:(Bolund Anneli Clea) > Engelska > Spirometric phenoty...

  • Wang, GangKarolinska Institutet (författare)

Spirometric phenotypes from early childhood to young adulthood : a Chronic Airway Disease Early Stratification study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-09-29
  • ERS Publications,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-191192
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191192URI
  • https://doi.org/10.1183/23120541.00457-2021DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149174473URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.Methods: We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ⩾LLN, and FVC z-score Results: The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46).Conclusion: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hallberg, JennyKarolinska Institutet (författare)
  • Charalampopoulos, DimitriosMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom (författare)
  • Sanahuja, Maribel CasasISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
  • Breyer-Kohansal, RobabLudwig Boltzmann Institute for Lung Health, Vienna, Austria (författare)
  • Langhammer, ArnulfDept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway (författare)
  • Granell, RaquelMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom (författare)
  • Vonk, Judith M.Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands (författare)
  • Mian, AnnemiekThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands (författare)
  • Olvera, NúriaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain (författare)
  • Laustsen, Lisbeth MølgaardDept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark (författare)
  • Rönmark, EvaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)evra0004 (författare)
  • Abellan, AliciaKarolinska Institutet (författare)
  • Agusti, AlvarInstitut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain; Respiratory Institute, Hospital Clinic, Univ. Barcelona, Barcelona, Spain; CIBERESP (ISCiii), Barcelona, Spain (författare)
  • Arshad, Syed HasanDavid Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom (författare)
  • Bergström, AnnaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden (författare)
  • Boezen, H. MarikeDept of Epidemiology, University Medical Center Groningen, Groningen, Netherlands (författare)
  • Breyer, Marie-KathrinLudwig Boltzmann Institute for Lung Health, Vienna, Austria (författare)
  • Burghuber, OttoLudwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria (författare)
  • Bolund, Anneli CleaDept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark (författare)
  • Custovic, AdnanNational Heart and Lung Institute, Imperial College London, London, United Kingdom (författare)
  • Devereux, GrahamLiverpool School of Tropical Medicine, Liverpool, United Kingdom (författare)
  • Donaldson, Gavin C.National Heart and Lung Institute, Imperial College London, London, United Kingdom (författare)
  • Duijts, LiesbethThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands (författare)
  • Esplugues, AnaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain (författare)
  • Faner, RosaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
  • Ballester, FerranSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain (författare)
  • Garcia-Aymerich, JudithISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
  • Gehring, UlrikeInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (författare)
  • Haider, SadiaNational Heart and Lung Institute, Imperial College London, London, United Kingdom (författare)
  • Hartl, SylviaLudwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria (författare)
  • Backman, HelenaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)heaban01 (författare)
  • Holloway, John W.NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom (författare)
  • Koppelman, Gerard H.University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, Beatrix Children’s Hospital, University of Groningen, Groningen, Netherlands (författare)
  • Lertxundi, AitanaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Dept of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, Spain; BIODONOSTIA Health Research Institute, Donostia-San Sebastian, Spain (författare)
  • Holmen, Turid LingaasDept of Public Health and General Practice, HUNT Research Center, NTNU, Levanger, Norway (författare)
  • Lowe, LesleyDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom (författare)
  • Mensink-Bout, Sara M.The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands (författare)
  • Murray, Clare S.Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom (författare)
  • Roberts, GrahamDavid Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom (författare)
  • Hedman, Linnea,1979-Umeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)evli0029 (författare)
  • Schlünssen, ViviDept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark (författare)
  • Sigsgaard, TorbenDept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark (författare)
  • Simpson, AngelaDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom (författare)
  • Sunyer, JordiISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; IMIM-Parc Salut Mar, Barcelona, Spain (författare)
  • Torrent, Matiesib-salut, Area de Salut de Menorca, Menorca, Spain (författare)
  • Turner, StephenRoyal Aberdeen Children’s Hospital NHS Grampian, Aberdeen, United Kingdom (författare)
  • Van den Berge, MaartenUniversity Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (författare)
  • Vermeulen, Roel C.H.Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (författare)
  • Vikjord, Sigrid Anna AalbergDept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway; Dept of Medicine and Rehabilitation, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway (författare)
  • Wedzicha, Jadwiga A.National Heart and Lung Institute, Imperial College London, London, United Kingdom (författare)
  • van der Zee, Anke H. MaitlandDept of Respiratory Medicine, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, Netherlands; Pediatric Respiratory Medicine, Emma Children’s Hospital, Amsterdam UMC, Amsterdam, Netherlands (författare)
  • Melén, ErikKarolinska Institutet (författare)
  • Karolinska InstitutetMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:ERJ Open Research: ERS Publications7:42312-0541

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