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Lack of Association between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts

Maple-Grødem, Jodi (författare)
The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway
Paul, Kimberly C. (författare)
Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
Dalen, Ingvild (författare)
Department of Research, Section of Biostatistics, Stavanger University Hospital, Stavanger, Norway
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Ngo, Kathie J. (författare)
Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
Wong, Darice (författare)
Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States
Macleod, Angus D. (författare)
Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
Counsell, Carl E. (författare)
Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
Bäckström, David C, M.D. 1978- (författare)
Umeå universitet,Neurovetenskaper,Department of Neurology, And Department of Neuroscience, Yale University School of Medicine, CT, New Haven, United States
Forsgren, Lars (författare)
Umeå universitet,Neurovetenskaper
Tysnes, Ole-Bjørn (författare)
Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway
Kusters, Cynthia D.J. (författare)
Department of Human Genetics, University of California Los Angeles, CA, Los Angeles, United States
Fogel, Brent L. (författare)
Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States
Bronstein, Jeff M. (författare)
Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
Ritz, Beate (författare)
Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Department of Epidemiology, UCLA Fielding School of Public Health, CA, Los Angeles, United States; Department of Biostatistics, UCLA Fielding School of Public Health, CA, Los Angeles, United States
Alves, Guido (författare)
The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway; Department of Neurology, Stavanger University Hospital, Stavanger, Norway
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 (creator_code:org_t)
IOS Press, 2021
2021
Engelska.
Ingår i: Journal of Parkinson's Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 11:4, s. 1569-1578
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson's disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on lacking whether patients with GBA-associated PD differ in their risk of developing motor complications compared to the general PD population.Objective: To evaluate the association of GBA carrier status with the development of LIDS and MFs from early PD.Methods: Motor complications were recorded prospectively in 884 patients with PD from four longitudinal cohorts using part IV of the UPDRS or MDS-UPDRS. Subjects were followed for up to 11 years and the associations of GBA mutations with the development of motor complications were assessed using parametric accelerated failure time models.Results: In 439 patients from Europe, GBA mutations were detected in 53 (12.1%) patients and a total of 168 cases of LIDs and 258 cases of MF were observed. GBA carrier status was not associated with the time to develop LIDs (HR 0.78, 95%CI 0.47 to 1.26, p = 0.30) or MF (HR 1.19, 95%CI 0.84 to 1.70, p = 0.33). In the American cohorts, GBA mutations were detected in 36 (8.1%) patients and GBA carrier status was also not associated with the progression to LIDs (HR 1.08, 95%CI 0.55 to 2.14, p = 0.82) or MF (HR 1.22, 95%CI 0.74 to 2.04, p = 0.43).Conclusion: This study does not provide evidence that GBA-carrier status is associated with a higher risk of developing motor complications. Publication of studies with null results is vital to develop an accurate summary of the clinical features that impact patients with GBA-associated PD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

dyskinesias
GBA
motor complications
motor fluctuations
Parkinson's disease

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art (ämneskategori)

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