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  • Maple-Grødem, JodiThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway (författare)

Lack of Association between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • IOS Press,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-191319
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191319URI
  • https://doi.org/10.3233/jpd-212657DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson's disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on lacking whether patients with GBA-associated PD differ in their risk of developing motor complications compared to the general PD population.Objective: To evaluate the association of GBA carrier status with the development of LIDS and MFs from early PD.Methods: Motor complications were recorded prospectively in 884 patients with PD from four longitudinal cohorts using part IV of the UPDRS or MDS-UPDRS. Subjects were followed for up to 11 years and the associations of GBA mutations with the development of motor complications were assessed using parametric accelerated failure time models.Results: In 439 patients from Europe, GBA mutations were detected in 53 (12.1%) patients and a total of 168 cases of LIDs and 258 cases of MF were observed. GBA carrier status was not associated with the time to develop LIDs (HR 0.78, 95%CI 0.47 to 1.26, p = 0.30) or MF (HR 1.19, 95%CI 0.84 to 1.70, p = 0.33). In the American cohorts, GBA mutations were detected in 36 (8.1%) patients and GBA carrier status was also not associated with the progression to LIDs (HR 1.08, 95%CI 0.55 to 2.14, p = 0.82) or MF (HR 1.22, 95%CI 0.74 to 2.04, p = 0.43).Conclusion: This study does not provide evidence that GBA-carrier status is associated with a higher risk of developing motor complications. Publication of studies with null results is vital to develop an accurate summary of the clinical features that impact patients with GBA-associated PD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Paul, Kimberly C.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States (författare)
  • Dalen, IngvildDepartment of Research, Section of Biostatistics, Stavanger University Hospital, Stavanger, Norway (författare)
  • Ngo, Kathie J.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States (författare)
  • Wong, DariceDepartment of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States (författare)
  • Macleod, Angus D.Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom (författare)
  • Counsell, Carl E.Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom (författare)
  • Bäckström, David C,M.D.1978-Umeå universitet,Neurovetenskaper,Department of Neurology, And Department of Neuroscience, Yale University School of Medicine, CT, New Haven, United States(Swepub:umu)dadbam02 (författare)
  • Forsgren, LarsUmeå universitet,Neurovetenskaper(Swepub:umu)lafo0001 (författare)
  • Tysnes, Ole-BjørnDepartment of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway (författare)
  • Kusters, Cynthia D.J.Department of Human Genetics, University of California Los Angeles, CA, Los Angeles, United States (författare)
  • Fogel, Brent L.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States (författare)
  • Bronstein, Jeff M.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States (författare)
  • Ritz, BeateDepartment of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Department of Epidemiology, UCLA Fielding School of Public Health, CA, Los Angeles, United States; Department of Biostatistics, UCLA Fielding School of Public Health, CA, Los Angeles, United States (författare)
  • Alves, GuidoThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway; Department of Neurology, Stavanger University Hospital, Stavanger, Norway (författare)
  • The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, NorwayDepartment of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Parkinson's Disease: IOS Press11:4, s. 1569-15781877-71711877-718X

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