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Metabolic signature...
Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
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- Rothwell, Joseph A. (author)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, France
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- Murphy, Neil (author)
- International Agency for Research on Cancer, Lyon, France
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- Bešević, Jelena (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Kliemann, Nathalie (author)
- International Agency for Research on Cancer, Lyon, France
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- Jenab, Mazda (author)
- International Agency for Research on Cancer, Lyon, France
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, Lyon, France
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- Achaintre, David (author)
- International Agency for Research on Cancer, Lyon, France
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- Gicquiau, Audrey (author)
- International Agency for Research on Cancer, Lyon, France
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- Vozar, Béatrice (author)
- International Agency for Research on Cancer, Lyon, France
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- Scalbert, Augustin (author)
- International Agency for Research on Cancer, Lyon, France
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- Huybrechts, Inge (author)
- International Agency for Research on Cancer, Lyon, France
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- Freisling, Heinz (author)
- International Agency for Research on Cancer, Lyon, France
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- Prehn, Cornelia (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Adamski, Jerzy (author)
- Research Unit, Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Neuherberg, Germany
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- Cross, Amanda J. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Pala, Valeria Maria (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Boutron-Ruault, Marie-Christine (author)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
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- Dahm, Christina C. (author)
- Department of Public Health, Aarhus University, Aarhus C, Denmark
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- Overvad, Kim (author)
- Department of Public Health, Aarhus University, Aarhus C, Denmark
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- Gram, Inger Torhild (author)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Sandanger, Torkjel M. (author)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Skeie, Guri (author)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Jakszyn, Paula (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
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- Tsilidis, Kostas K. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Aleksandrova, Krasimira (author)
- Nutrition, Immunity and Metabolism Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Hughes, David J. (author)
- School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland
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- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi
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- Bodén, Stina (author)
- Umeå universitet,Onkologi
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- Sánchez, Maria-José (author)
- CIBER Epidemiología y Salud Pública, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Schmidt, Julie A. (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Katzke, Verena (author)
- Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
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- Kühn, Tilman (author)
- Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
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- Colorado-Yohar, Sandra (author)
- Department of Epidemiology, Murcia Regional Health Council, Instituto Murciano de Investigatión Biomédica (IMIB)–Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Tumino, Rosario (author)
- Cancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy
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- Bueno-de-Mesquita, Bas (author)
- Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, The Netherlands, BA Bilthoven, Netherlands
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- Vineis, Paolo (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy
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- Masala, Giovanna (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy
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- Panico, Salvatore (author)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Eriksen, Anne Kirstine (author)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Aune, Dagfinn (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, Lyon, France
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- Severi, Gianluca (author)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
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- Chajès, Véronique (author)
- International Agency for Research on Cancer, Lyon, France
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- Gunter, Marc J. (author)
- International Agency for Research on Cancer, Lyon, France
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 20:5, s. e1061-e1082
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Colorectal Neoplasm
- Risk Factors
- Targeted Metabolomics
- World Cancer Research Fund/American Institute for Cancer Research Recommendations
- Oncology
- onkologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rothwell, Joseph ...
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Murphy, Neil
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Bešević, Jelena
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Kliemann, Nathal ...
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Jenab, Mazda
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Ferrari, Pietro
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show more...
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Achaintre, David
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Gicquiau, Audrey
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Vozar, Béatrice
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Scalbert, August ...
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Huybrechts, Inge
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Freisling, Heinz
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Prehn, Cornelia
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Adamski, Jerzy
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Cross, Amanda J.
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Pala, Valeria Ma ...
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Boutron-Ruault, ...
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Dahm, Christina ...
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Overvad, Kim
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Gram, Inger Torh ...
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Sandanger, Torkj ...
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Skeie, Guri
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Jakszyn, Paula
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Tsilidis, Kostas ...
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Aleksandrova, Kr ...
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Schulze, Matthia ...
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Hughes, David J.
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van Guelpen, Bet ...
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Bodén, Stina
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Sánchez, Maria-J ...
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Schmidt, Julie A ...
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Katzke, Verena
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Kühn, Tilman
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Colorado-Yohar, ...
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Tumino, Rosario
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Bueno-de-Mesquit ...
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Vineis, Paolo
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Masala, Giovanna
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Panico, Salvator ...
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Eriksen, Anne Ki ...
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Tjønneland, Anne
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Aune, Dagfinn
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Weiderpass, Elis ...
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Severi, Gianluca
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Chajès, Véroniqu ...
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Gunter, Marc J.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Clinical Gastroe ...
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Umeå University