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Metabolic signature...
Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
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- Rothwell, Joseph A. (författare)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, France
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- Murphy, Neil (författare)
- International Agency for Research on Cancer, Lyon, France
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- Bešević, Jelena (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Kliemann, Nathalie (författare)
- International Agency for Research on Cancer, Lyon, France
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, Lyon, France
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, Lyon, France
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- Achaintre, David (författare)
- International Agency for Research on Cancer, Lyon, France
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- Gicquiau, Audrey (författare)
- International Agency for Research on Cancer, Lyon, France
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- Vozar, Béatrice (författare)
- International Agency for Research on Cancer, Lyon, France
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, Lyon, France
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- Huybrechts, Inge (författare)
- International Agency for Research on Cancer, Lyon, France
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, Lyon, France
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- Prehn, Cornelia (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Adamski, Jerzy (författare)
- Research Unit, Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Neuherberg, Germany
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- Cross, Amanda J. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Pala, Valeria Maria (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Boutron-Ruault, Marie-Christine (författare)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
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- Dahm, Christina C. (författare)
- Department of Public Health, Aarhus University, Aarhus C, Denmark
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- Overvad, Kim (författare)
- Department of Public Health, Aarhus University, Aarhus C, Denmark
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- Gram, Inger Torhild (författare)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Sandanger, Torkjel M. (författare)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Skeie, Guri (författare)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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- Jakszyn, Paula (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
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- Tsilidis, Kostas K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Aleksandrova, Krasimira (författare)
- Nutrition, Immunity and Metabolism Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Hughes, David J. (författare)
- School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland
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- van Guelpen, Bethany (författare)
- Umeå universitet,Onkologi
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- Bodén, Stina (författare)
- Umeå universitet,Onkologi
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- Sánchez, Maria-José (författare)
- CIBER Epidemiología y Salud Pública, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Schmidt, Julie A. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Katzke, Verena (författare)
- Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
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- Kühn, Tilman (författare)
- Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
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- Colorado-Yohar, Sandra (författare)
- Department of Epidemiology, Murcia Regional Health Council, Instituto Murciano de Investigatión Biomédica (IMIB)–Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy
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- Bueno-de-Mesquita, Bas (författare)
- Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, The Netherlands, BA Bilthoven, Netherlands
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- Vineis, Paolo (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy
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- Masala, Giovanna (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy
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- Panico, Salvatore (författare)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Eriksen, Anne Kirstine (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Aune, Dagfinn (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, Lyon, France
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- Severi, Gianluca (författare)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
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- Chajès, Véronique (författare)
- International Agency for Research on Cancer, Lyon, France
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, Lyon, France
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 20:5, s. e1061-e1082
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.cghjourna...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Colorectal Neoplasm
- Risk Factors
- Targeted Metabolomics
- World Cancer Research Fund/American Institute for Cancer Research Recommendations
- Oncology
- onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Rothwell, Joseph ...
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Murphy, Neil
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Bešević, Jelena
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Kliemann, Nathal ...
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Jenab, Mazda
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Ferrari, Pietro
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visa fler...
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Achaintre, David
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Gicquiau, Audrey
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Vozar, Béatrice
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Scalbert, August ...
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Huybrechts, Inge
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Freisling, Heinz
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Prehn, Cornelia
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Adamski, Jerzy
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Cross, Amanda J.
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Pala, Valeria Ma ...
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Boutron-Ruault, ...
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Dahm, Christina ...
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Overvad, Kim
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Gram, Inger Torh ...
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Sandanger, Torkj ...
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Skeie, Guri
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Jakszyn, Paula
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Tsilidis, Kostas ...
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Aleksandrova, Kr ...
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Schulze, Matthia ...
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Hughes, David J.
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van Guelpen, Bet ...
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Bodén, Stina
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Sánchez, Maria-J ...
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Schmidt, Julie A ...
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Katzke, Verena
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Kühn, Tilman
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Colorado-Yohar, ...
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Tumino, Rosario
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Bueno-de-Mesquit ...
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Vineis, Paolo
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Masala, Giovanna
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Panico, Salvator ...
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Eriksen, Anne Ki ...
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Tjønneland, Anne
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Aune, Dagfinn
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Weiderpass, Elis ...
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Severi, Gianluca
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Chajès, Véroniqu ...
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Gunter, Marc J.
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