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Patient-reported symptom severity in a nationwide myasthenia gravis cohort : cross-sectional analysis of the Swedish GEMG study

Petersson, Malin (författare)
Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
Feresiadou, Amalia (författare)
Uppsala universitet,Landtblom: Neurovetenskap
Jons, Daniel (författare)
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden.
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Ilinca, Andreea (författare)
Department of Clinical Sciences Lund, Neurology, Lund University, Skåne University Hospital, Malmö, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Neurol, Malmö, Sweden.
Lundin, Fredrik (författare)
Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Linköping Univ, Dept Neurol, Linköping, Sweden.;Linköping Univ, Div Neurobiol, Dept Biomed & Clin Sci, Linköping, Sweden.
Johansson, Rune (författare)
Department of Neurology and Rehabilitation, Karlstad Central Hospital, Karlstad, Sweden,Karlstad Cent Hosp, Dept Neurol & Rehabil, Karlstad, Sweden.
Budzianowska, Anna (författare)
Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Linköping Univ, Div Neurobiol, Dept Biomed & Clin Sci, Linköping, Sweden.;Reg Jönköping Cty, Sect Neurol, Dept Internal Med Jönköping, Jönköping, Sweden.
Roos, Anna-Karin (författare)
Umeå universitet,Neurovetenskaper,Unit of Neurology, Department of Clinical Science, Neurosciences, Umeå University, Östersund, Sweden,Umeå Univ, Unit Neurol, Dept Clin Sci, Neurosci, Östersund, Sweden.
Kågström, Viktor (författare)
Rehabilitation clinic, Sundsvall's hospital, Sundsvall, Sweden,Sundsvall Hosp, Rehabil Clin, Sundsvall, Sweden.
Gunnarsson, Martin, 1973- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology,Örebro Univ, Fac Med & Hlth, Dept Neurol, Örebro, Sweden.
Sundström, Peter (författare)
Umeå universitet,Neurovetenskaper,Department of Clinical Science, Neurosciences, Umeå University, Sweden,Umeå Univ, Neurosci, Dept Clin Sci, Umeå, Sweden.
Piehl, Fredrik (författare)
Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden.
Brauner, Susanna (författare)
Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden (creator_code:org_t)
Lippincott Williams & Wilkins, 2021
2021
Engelska.
Ingår i: Neurology. - : Lippincott Williams & Wilkins. - 0028-3878 .- 1526-632X. ; 97:14, s. e1382-e1391
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://liu.diva-por... (primary) (Raw object)
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background and Objectives: To describe myasthenia gravis activities of daily living (MG-ADL) in relation to clinical characteristics in a large Swedish nationwide cohort.Methods: In a cross-sectional prevalence cohort study, the Genes and Environment in Myasthenia Gravis study, performed from November 2018 through August 2019, patients with myasthenia gravis (MG) were invited to submit an extensive 106-item life environment questionnaire, including the MG-ADL score. Patients were classified into early-onset MG (EOMG, <50 years), late-onset MG (LOMG, >= 50 years), or thymoma-associated MG (TAMG). Comparisons of disease-specific characteristics were made between subgroups, sexes, and different MG-ADL scores.Results: A total of 1,077 patients were included, yielding a 74% response rate: 505 (47%) were classified as EOMG, 520 (48%) LOMG, and 45 (4%) TAMG. Mean age at inclusion was 64.3 years (SD 15.7) and mean disease duration was 14.6 years (SD 14.0). Complete MG-ADL scores (n = 1,035) ranged from 0p to 18p, where 26% reported a score of 0p. Higher MG-ADL scores were associated with female sex, obesity, and diagnostic delay (odds ratio [OR] 1.62, 1.72, and 1.69; p(adj) = 0.017, 0.013, and 0.008) and inversely correlated with high educational attainment (OR 0.59; p(adj) = 0.02), but not with age at inclusion, disease subtype, or disease duration. Almost half of the population (47%) reported MG-ADL >= 3p, corresponding to an unsatisfactory symptom state.Discussion: In this nationwide study, comprising more than 40% of the prevalent MG population in Sweden, almost half of the patients reported current disease symptoms associated with an unsatisfactory symptom state, indicating the need for improved treatment options.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)

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