SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Hansen Eva)
 

Search: WFRF:(Hansen Eva) > Prospective evaluat...

  • Mukama, TrasiasDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)

Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-14
  • Springer Nature,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-191667
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191667URI
  • https://doi.org/10.1038/s41416-021-01697-zDOI
  • https://lup.lub.lu.se/record/6fd53ff2-c965-4093-b3a6-a533a67787b9URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer.Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. We evaluated the discriminatory performance of the proteins as potential early diagnostic biomarkers of ovarian cancer.Results: Nine of the 92 markers; CA125, HE4, FOLR1, KLK11, WISP1, MDK, CXCL13, MSLN and ADAM8 showed an area under the ROC curve (AUC) of ≥0.70 for discriminating between women diagnosed with ovarian cancer and women who remained cancer-free. All, except ADAM8, had shown at least equal discrimination in previous case-control comparisons. The discrimination of the biomarkers, however, was low for the lag-time of >9–18 months and paired combinations of CA125 with any of the 8 markers did not improve discrimination compared to CA125 alone.Conclusion: Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0–9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fortner, Renée TurzanskiDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)
  • Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)
  • Hynes, Lucas CoryDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)
  • Petrera, AgneseResearch Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany (author)
  • Hauck, Stefanie M.Research Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany (author)
  • Johnson, TheronDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)
  • Schulze, MatthiasDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany (author)
  • Schiborn, CatarinaDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany (author)
  • Rostgaard-Hansen, Agnetha LinnDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark (author)
  • Tjønneland, AnneDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark (author)
  • Overvad, KimDepartment of Public Health, Aarhus University, Bartholins Alle 2, Aarhus C, Denmark (author)
  • Pérez, María José SánchezEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP) (author)
  • Crous-Bou, MartaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University,Bellvitge University Hospital-IDIBELL (author)
  • Chirlaque, María-DoloresCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain (author)
  • Amiano, PilarCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Group of Epidemiology of Chronic and Communicable Diseases, San Sebastián, Spain (author)
  • Ardanaz, EvaCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (author)
  • Watts, Eleanor L.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (author)
  • Travis, Ruth C.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (author)
  • Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Via Santena 7, Turin, Italy (author)
  • Grioni, SaraEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy (author)
  • Masala, GiovannaInstitute of Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (author)
  • Signoriello, SimonaDipartimento di Salute Mentale e Fisica e Medicina Preventiva, Vanvitelli University, Naples, Italy (author)
  • Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy (author)
  • Gram, Inger T.Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (author)
  • Sandanger, Torkjel M.Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (author)
  • Sartor, HannaLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)med-hso (author)
  • Lundin, EvaUmeå University,Umeå universitet,Patologi(Swepub:umu)evlu0001 (author)
  • Idahl, Annika,1965-Umeå University,Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002 (author)
  • Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Dossus, LaureNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France (author)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France (author)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)
  • Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, GermanyResearch Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Springer Nature126, s. 1301-13090007-09201532-1827

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view